Results 161 to 170 of about 78,404 (311)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

General provisions to evaluate a technical state and to extend an operation life of VVER vessel

open access: yes, 2007
На підставі оглядового аналізу передового міжнародного та вітчизняного досвіду узагальнено та сформульовано основні положення й вимоги до оцінки технічного стану та технічних обґрунтувань по продовженню експлуатації корпусів ВВЕР.На основании обзорного ...
Колыханов, В.Н.   +6 more
core  

Transferable Ageing Provisions in Individual Health Insurance Contracts [PDF]

open access: yes
We consider lifetime health insurance contracts in which ageing provisions are used to smooth the premium profile. The stock of capital accumulated for each individual can be split into two parts: a premium insurance and an annuitised life insurance ...
Volker Meier   +2 more
core   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Evaluation of warranty provisions on ODOT construction projects

open access: yes, 2003
"University of Cincinnati and Purdue University."; "November 2003."; Includes bibliographical references (p. 155-158).; Final report.; Performed by University of Cincinnati, Dept. of Civil and Environmental Engineering, sponsored by the Ohio Dept.
University of Cincinnati. Dept. of Civil and Environmental Engineering.   +1 more
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Change trends of food provisions in China

open access: yes, 2010
This paper analyzes change trend of farmland food production, grassland food provision, marine and inland aquatic products, and imports and exports in terms of calorie, protein and fat under consideration of Grain-for-Green program and urbanization.
Lu, Yi-Ming   +6 more
core  

Regulatory provisions for post-release monitoring of genetically modified organisms in Africa. [PDF]

open access: yesFront Bioeng Biotechnol
Njagi J   +5 more
europepmc   +1 more source

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