Results 171 to 180 of about 78,404 (311)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Public policy and life insurance [PDF]

Public policy ; Life insurance companies ; Insurance ...
Gerard M. Brannon
core  

Dense retrieval and reranking for referenced provisions in electric power audit systems. [PDF]

PLoS One
Meng Q, He Y, Hussain S, Zhou F, Xu J, Zhao G, Xiong D.   +6 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Glagolitic moral-casuistic provisions of the bishops of Nin – the 17th and 18th centuries

, 2015
Crkva je imala veliki utjecaj na svakodnevni život ljudi kroz sakramente, propovijedi, učenje vjeronauka, svete mise, bratovštine, ali i kroz moralno-kazuističke odredbe koje su svojim svećenicima slali biskupi.
Franov-Živković, Grozdana, Grozdana Franov-Živković   +1 more
core  

Impact of China's Drug Regulatory Reforms on the Development of Anti-Tumor Drugs. [PDF]

Cancer Commun (Lond)
Tang L, Yuan L, Geng Y, Yang Z, Huang G.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Leave policy after stillbirth in LMICs: how much are we thinking about bereaved mothers? A scoping review. [PDF]

BMJ Open
Pandey AK, Gautam D, Sachdeva R, Sheikh N, Sharma P, Agarwal P, Pandey A, Sehrawat A, M BT, Sah RK, Neogi SB.   +10 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A manager-centred perspective on work-life integration

, 2015
Decades of research has shown that the uptake of workplace ‘flexibility’ provisions set out in organizational/HR policies rests heavily on the support of line managers.
McDonald, Paula K., Cathcart, Abby
core