Results 181 to 190 of about 9,468 (203)

Roles for MSI2 and PROX1 in hematopoietic stem cell activity

Current Opinion in Hematology, 2011
The MSI2 and PROX1 proteins are increasingly recognized for their critical roles in the biology of primitive hematopoietic cells and for their potential contributions to leukemic pathogenesis. Here we summarize the studies that have shed light on the hematopoietic-specific roles of MSI2 and PROX1 and give an overview of the molecular mechanisms ...
Kristin J, Hope, Guy, Sauvageau
openaire   +2 more sources

PROX1: A Key Regulator of Hepatocyte Identity and Tumorigenesis

Cancer Research
During ontogeny, the modulation of cell fate plasticity in stem cells is meticulously controlled as they undergo differentiation into distinct cell lineages. Dysregulation of this plasticity can result in pathologic conditions, such as oncogenesis. Transcription factors are pivotal in orchestrating this cellular transition by initiating gene expression
Terence Kin Wah Lee, Stephanie Ma
openaire   +2 more sources

Hepatocyte migration during liver development requires Prox1

Nature Genetics, 2000
Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.
B, Sosa-Pineda, J T, Wigle, G, Oliver
openaire   +2 more sources

Prox1 function is crucial for mouse lens-fibre elongation

Nature Genetics, 1999
Although insights have emerged regarding genes controlling the early stages of eye formation, little is known about lens-fibre differentiation and elongation. The expression pattern of the Prox1 homeobox gene suggests it has a role in a variety of embryonic tissues, including lens.
J T, Wigle, K, Chowdhury, P, Gruss, G, Oliver   +3 more
openaire   +2 more sources

PROX1 is involved in progression of rectal neuroendocrine tumors, NETs

Virchows Archiv, 2015
PROX1 is a homeobox transcription factor involved in the development of the lens, liver and heart and found upregulated in colorectal cancers. We studied PROX1 expression by immunohistochemistry in rectal neuroendocrine tumors (NETs). Approximately 10 to 15 % of gastroenteropancreatic NETs occur in the rectum, and some may metastasize.
Haglund Caj, Hagstrom Jaana, Arola Johanna, Alitalo Kari, Valimaki Matti J., Haapasalo H, Haglund Caj, Hagstrom Jaana, Arola Johanna, Alitalo Kari, Valimaki Matti J.   +10 more
openaire   +2 more sources

Gene regulation by homeobox transcription factor Prox1 in murine hepatoblasts

Cell and Tissue Research, 2007
The homeobox transcription factor Prox1 is expressed in embryonic hepatoblasts and remains expressed in adult hepatocytes. Prox1-null mice show severe deficiencies in liver development, although the underlying mechanisms are unknown. We have studied the effects of Prox1 on the transcriptional profile of met-murine hepatocytes (MMH) obtained on ...
PAPOUTSI M, DUDAS J, BECKER J, TRIPODI, Marco, OPITZ L, RAMADORI G, WILTING J.   +6 more
openaire   +4 more sources

Immunohistochemical investigation of the transcription factor PROX1 emphasizing on neuroendocrine neoplasms

Medical Molecular Morphology
Prospero homeobox protein 1 (PROX1) is aberrantly expressed in tumors, including neuroendocrine neoplasms (NENs); however, the detailed expression pattern remains elusive. This study aimed to immunohistochemically assess PROX1 expression. Immunohistochemistry (IHC) for PROX1 was performed on tissue microarrays of normal tissues (n = 107), NENs (n = 152)
Kanata Kojima, Kouhei Sakurai, Tatsuya Ando, Yasuhiro Sakai, Mako Ochiai, Taku Kato, Hiroyasu Ito   +6 more
openaire   +2 more sources

BINDING MOLECULE ABLE TO NEUTRALIZE PROX1 PROTEIN

2023
KIM JIN WOO, LEE EUN JUNG
openaire   +2 more sources

Prox1 expression patterns in the developing and adult murine brain

Developmental Dynamics, 2007
Guillermo Oliver
exaly  

Expression and prognostic value of transcription factor PROX1 in colorectal cancer

British Journal of Cancer, 2011
Johan Lundin, Kari Alitalo, P Bono
exaly