Results 31 to 40 of about 2,188 (132)

Proximal Junctional Kyphosis in Modern Spine Surgery: Why Is it So Common?

Spine Surgery and Related Research, 2023
In the past few decades, proximal junctional kyphosis (PJK) has emerged as a new complication after instrumented spinal fusion in adult and pediatric spinal deformities.
Jean Dubousset, Bassel G. Diebo
doaj   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Staged Lateral Lumbar Interbody Fusion Targeting Driver and Compensatory Structural Segments for Adult Degenerative Scoliosis: A Novel Strategy and Early Outcomes

Orthopaedic Surgery, EarlyView.
Targeting driver and structural vertebrae via LLIF is an effective, minimally invasive strategy for ADS. It offers substantial deformity correction, symptom relief, and progressive postoperative self‐correction while significantly reducing surgical trauma compared to traditional long‐segment fusions.
Tianyong Wen, Liukun Xu, Peng Lu, Yang Zhang, Wei Ji, Yang Zheng, Zhicheng Zhang, Tiansheng Sun   +7 more
wiley   +1 more source

The use of hooks in upper instrumented vertebra to prevent proximal junctional complications: a systematic review and meta-analysis

BMC Surgery
Background Proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) are leading complications after adult spinal deformity (ASD) surgery.
Hifza Babar, Dong Li, Jie Li, Zhen Liu, Zezhang Zhu, Yong Qiu   +5 more
doaj   +1 more source

Multidimensional Management of Degenerative Scoliosis: A Comprehensive Narrative Review Integrating Diagnostic Assessment, Surgical Decision‐Making, and Patient‐Centered Outcomes

Orthopaedic Surgery, EarlyView.
The contemporary, multidimensional management pathway for de novo degenerative lumbar scoliosis, integrating quantitative diagnosis (coronal Cobb angle and Pfirrmann disk grading), multidimensional preoperative evaluation (CT Hounsfield Units, spinopelvic alignment, paraspinal muscle quality), stratified treatment (conservative care vs.
Yaobin Wang, Xingyu Zhao, Kai Wang, Zhenlei Liu, Lei Zhang, Shanhang Jia, He Wang, Weikang Zhang, Yuhua Yang, Tong Xu, Hao Wu   +10 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Contiguous Lumbar Bilateral Pars Defects at L3 and L4 (With Intact L5): Treated With Pedicle Screw Fixation and Interbody Fusion: A Case Report With Literature Review

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 42‐year‐old woman had chronic L4 pars defect with Grade 2 spondylolisthesis and acute L3 pars fractures after trauma, causing back pain, sensory, and motor deficits. She underwent L3–L5 pedicle screw fixation with interbody fusion. Postoperatively, she showed rapid pain relief, neurological improvement, and stable spinal alignment on follow ...
Muhammad Rizwan Ali, Muhammad Jawad Saleem, Ali Shahid, Muhammad Suliman Sajid, Muhammad Haris, Shayan Asmat, Noor ul Subah Afzal, Mohammad Al Diab Al Azzawi   +7 more
wiley   +1 more source

Global Alignment and Proportion (GAP) Score in Predicting Mechanical Complications After Long‐Segment Fixation for Chinese Geriatric Patients With Adult Degenerative Scoliosis: A Mid‐Term Comparative Study

Orthopaedic Surgery, Volume 18, Issue 10, Page 2195-2204, October 2026.
In our study, we found that the GAP score could effectively predict the risk of mechanical complications after long‐segment fixation surgery in geriatric ADS patients. ABSTRACT Objectives The predictive value of the global alignment and proportion (GAP) score in the Chinese geriatric population, which has unique demographic and degenerative ...
Xiangyao Sun, Jiang Huang, Yuqi Liu, Siyuan Sun, Li Cao, Juyong Wang, Shibao Lu   +6 more
wiley   +1 more source

Early Versus Late Enzyme Replacement Therapy in Siblings With Morquio A Syndrome: Insights Into Therapeutic Timing

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT Enzyme replacement therapy (ERT) with elosulfase alfa is the only approved treatment for mucopolysaccharidosis type IVA. This case report delineates the 5‐year outcomes of ERT in two Korean siblings with mucopolysaccharidosis type IVA, with the younger sibling initiating treatment at 0.8 years of age and the older one at 5.4 years.
Shinjie Choi, Hyoungmin Kim, Tae‐Joon Cho, Jung Min Ko   +3 more
wiley   +1 more source

Combine Short‐Segment Fixation and Leverage Reduction Technique to Correct Kyphotic Angle in Kümmell's Disease

Orthopaedic Surgery, Volume 18, Issue 7, Page 1518-1528, July 2026.
This study introduces a leverage reduction technique with short‐segment fixation for Kümmell's disease and kyphosis deformity. This advanced approach reliably restores vertebral height, corrects kyphosis, and improves clinical outcomes. ABSTRACT Objective Kümmell disease is a prevalent spinal condition characterized by vertebral fractures and ...
Yunwei Long, Guangzi Chen, Delu Zeng, Xiangyu Tang, Chaoxu Liu   +4 more
wiley   +1 more source