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Androgens stimulate proximal tubule transport
Gender Medicine, 2008Disrupting the enzyme cytochrome P4a14 in mice leads to hypertension, which is more severe in male than in female mice and appears to be due to androgen excess. Androgens are known to increase expression of angiotensinogen,but the effect of androgens on proximal tubule transport is unknown.These studies aimed to determine the effect of androgens on ...
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Calcium Transport by the Proximal Tubule
1986Taken together the results of these in vivo microperfusion experiments indicate that calcium absorption by the proximal tubule depends on more than one transport mechanism. We have observed that net calcium flux is affected by changes in calcium ion activity (even with constant total calcium concentration) and in transepithelial voltage.
F S, Wright, K, Bomsztyk
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1994
The morphology of the proximal tubule cells was covered briefly in Chapter 2, but will be considered in more detail here. The proximal tubule is divisible into the convoluted portion, or pars convoluta, which begins immediately behind the glomerulus, and the straight portion, or pars recta, which passes into the medulla to become the loop of Henle. The
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The morphology of the proximal tubule cells was covered briefly in Chapter 2, but will be considered in more detail here. The proximal tubule is divisible into the convoluted portion, or pars convoluta, which begins immediately behind the glomerulus, and the straight portion, or pars recta, which passes into the medulla to become the loop of Henle. The
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Proximal tubule tendrils: Fact or artefact
American Journal of Anatomy, 1976AbstractTendrils have been reported to radiate from luminal surfaces of proximal tubules in rat kidneys by Andrews and Porter ('74) using scanning microscopy, but they were not seen by Bulger et al. ('74). In this study, the perfusion procedure of Andrews and Porter was re‐investigated.
R E, Bulger, F L, Siegel, R, Pendergrass
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Amiloride analogues inhibit proximal tubule metabolism
American Journal of Physiology-Cell Physiology, 1986The effects of two amiloride analogues, ethylisopropylamiloride and methylisopropylamiloride, were tested on active Na+ transport and oxidative metabolism of a rabbit proximal renal tubule suspension. These two analogues have been recently reported to inhibit Na+-H+ antiport activity of various tissues with greater potency than amiloride.
S P, Soltoff, E J, Cragoe, L J, Mandel
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Functional Ultrastructure of the Proximal Tubule
Comprehensive Physiology, 1991Abstract The sections in this article are: Location of Proximal Tubule Fixation of Proximal Tubule Cells for Electron Microscopy Ultrastructure of the Mammalian Proximal Tubule Cell
Maunsbach, Arvid B. +1 more
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Endocytic Receptors in the Renal Proximal Tubule
Physiology, 2012Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ...
Christensen, Erik Ilsø +4 more
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Inulin loss from rat proximal tubule
Experientia, 1966Bei Durchstromung mit natriumfreier Losung verschwindet sowohl H3-als auch C14-markiertes Inulin aus dem proximalen Tubulus der Rattenniere in vivo, nicht aber wenn die Perfusionslosung die normale Natriumkonzentration enthalt.
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Biotransformation Studies Using Rat Proximal Tubule Cells
Current Protocols in Toxicology, 2004AbstractThe proximal tubule is the main target for nephrotoxic substances due to its specific properties, including efficient drug transport and biotransformation potential. The availability of a pure population of proximal tubule cells (PT cells) as a model to study a range of biological, pharmacological, and toxicological parameters is, therefore, of
Schaaf, G.J. +2 more
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Primary Kidney Proximal Tubule Cells
2004Primary rabbit kidney epithelial cell cultures can be obtained that express renal proximal tubule functions. Toward these ends, renal proximal tubules are purified from the rabbit kidney by the method of Brendel and Meezan. To summarize, each kidney is perfused with iron oxide, which becomes associated with glomeruli.
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