Results 351 to 360 of about 611,505 (395)
Some of the next articles are maybe not open access.
In Vitro Proximal Tubule Perfusion Preparation
2003Isolation and perfusion of single nephron segments was first described by Burg et al. (1) in 1966. This technique has allowed us to study both transepithelial and transmembrane transport in individual nephron segments, including the proximal tubule, under carefully controlled circumstances.
J L, Garvin, P J, Harris
openaire +2 more sources
cAMP-Adenosine Pathway in the Proximal Tubule
The Journal of Pharmacology and Experimental Therapeutics, 2006The "extracellular cAMP-adenosine pathway" refers to the conversion of cAMP to AMP by ecto-phosphodiesterase, followed by metabolism of AMP to adenosine by ecto-5'-nucleotidase, with all the steps occurring in the extracellular compartment. This study investigated whether the extracellular cAMP-adenosine pathway exists in proximal tubules.
Edwin K, Jackson +5 more
openaire +2 more sources
Intracellular pH in snake renal proximal tubules
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1995Intracellular pH (pHi) was studied in isolated proximal renal tubules of garter snakes (Thamnophis spp.) with oil-filled lumens under control conditions [N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES)-buffered medium with pH 7.4 at 25 degrees C] and in response to NH4Cl pulse.
Y K, Kim, W H, Dantzler
openaire +2 more sources
Oxalate secretion in the rat proximal tubule
American Journal of Physiology-Renal Physiology, 1981Simultaneous capillary and luminal microperfusion studies in the proximal convoluted tubule of the rat were performed to examine the transepithelial secretory flux of [14C]oxalate. Increases in the concentration of oxalate in the capillary solution from 0.096 to 4.3 mM resulted in progressively higher rates of oxalate secretion into the lumen. Further
T F, Knight +3 more
openaire +2 more sources
Macrophages induce apoptosis in proximal tubule cells
Pediatric Nephrology, 2003Macrophages play important roles during renal inflammation. Infiltrating macrophages produce proinflammatory mediators and induce apoptosis in a variety of target cells. Because proximal tubules are frequently damaged in inflammatory processes, we investigated murine macrophages (J774) in the induction of apoptosis in murine PKSV-PR proximal tubule ...
Bärbel, Lange-Sperandio +3 more
openaire +2 more sources
Receptor-mediated endocytosis in renal proximal tubule
Pflügers Archiv - European Journal of Physiology, 2009Proteins filtered in renal glomeruli are removed from the tubular fluid by endocytosis in the proximal tubule mediated by the two receptors megalin and cubilin. After endocytic uptake, the proteins are transferred to lysosomes for degradation, while the receptors are returned to the apical cell membrane by receptor recycling in dense apical tubules. In
Christensen, Erik I. +2 more
openaire +2 more sources
Nephrotoxicity and the Proximal Tubule
Nephron Physiology, 2003Cadmium (Cd<sup>2+</sup>) is a non-essential heavy metal, which is taken up from the environment into the body through pulmonary and enteral pathways. The S1 segment of the kidney proximal tubule (PT) is a major target of chronic Cd<sup>2+</sup> toxicity.
openaire +1 more source
Chloride Transport in the Proximal Renal Tubule
Annual Review of Physiology, 1988Our knowledge of chloride transport along the nephron has greatly expanded. Whereas for a long time it was assumed that chloride ions were reabsorbed entirely passively with sodium--the "mendicant" role of chloride, more recent studies suggest that several distinct reabsorptive transport mechanisms operate in parallel.
L, Schild, G, Giebisch, R, Green
openaire +2 more sources
Transcellular Chloride Pathways in Ambystoma Proximal Tubule
The Journal of Membrane Biology, 1998The transport mechanisms of Ambystoma proximal tubule that mediate transcellular Cl- absorption linked to Na+ were investigated in isolated perfused tubules using Cl--selective and voltage-recording microelectrodes. In control solutions intracellular activity of Cl- (aiCl) is 11.3 +/- 0.5 mm, the basolateral (V1), apical (V2), and transepithelial (V3 ...
S, Abdulnour-Nakhoul, E L, Boulpaep
openaire +2 more sources
Developmental changes in proximal tubule NaCl transport
Pediatric Nephrology, 2007The proximal tubule reabsorbs two thirds of the filtered NaCl in an isoosmotic fashion. In the adult proximal tubule, active NaCl transport is mediated by the parallel operation of Na(+)/H(+) and Cl(-)/base exchangers, and a substantive amount of chloride transport occurs passively across the paracellular pathway.
openaire +2 more sources