Results 111 to 120 of about 2,343,632 (295)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Thermoelectric effects in superconducting proximity structures

, 2007
Attaching a superconductor in good contact with a normal metal makes rise to a proximity effect where the superconducting correlations leak into the normal metal.
A. Parsons, A. Parsons, A. Schmid, A.A. Golubov, A.F. Volkov, A.F. Volkov, A.F. Volkov, B.J. Wees van, C.J. Lambert, C.J. Pethick, D.A. Dikin, D.A. Dikin, E. Zhao, E.V. Bezuglyi, F. Giazotto, F.K. Wilhelm, G. Eilenberger, G. Srivastava, G.R. Boogaard, H. Courtois, H. Courtois, H. Pothier, H.B. Callen, H.B.G. Casimir, J. Clarke, J. Clarke, J. Eom, J. Huang, J. Kutchinsky, J. Zou, J.J.A. Baselmans, J.J.A. Baselmans, J.J.A. Baselmans, K.D. Usadel, K.K. Likharev, L. Onsager, M. Cutler, M. Meschke, M.S. Crosser, N.B. Kopnin, N.R. Claughton, P. Charlat, P. Samuelsson, P. Virtanen, P. Virtanen, P. Virtanen, P. Virtanen, P.G.N. Vegvar de, R. Seviour, R. Shaikhaidarov, S.-K. Yip, S.G. den Hartog, T. Löfwander, T. Schäpers, T.H. Stoof, T.T. Heikkilä, T.T. Heikkilä, T.T. Heikkilä, V.L. Ginzburg, V.R. Kogan, V.T. Petrashov, V.T. Petrashov, W. Belzig, W. Belzig, Y.M. Galperin, Y.V. Nazarov, Y.V. Nazarov, Z. Jiang, Z. Jiang, Z. Jiang   +69 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Injonction à la transparence dans le fact-checking : de l’idéal de l’objectivité à une tentative de proximité

Sociologies, 2020
Our contribution examines how Brazilian online media specialized in fact-checking mobilize transparency in their discursive productions during the period of the last presidential campaign (2018).
Lorreine Petters
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Triplet proximity effect in FSF trilayers

, 2003
We study the critical temperature T_c of FSF trilayers (F is a ferromagnet, S is a singlet superconductor), where the triplet superconducting component is generated at noncollinear magnetizations of the F layers.
A. A. Golubov, A. I. Buzdin, A. Kadigrobov, G. Deutscher, L. N. Bulaevskii, L. R. Tagirov, M. G. Khusainov, M. Yu. Kupriyanov, M. Yu. Kupriyanov, V. L. Berezinskii, Ya. V. Fominov, Ya. V. Fominov   +11 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Attributing Air Pollutant Exposure to Emission Sources with Proximity Sensing

Atmosphere, 2019
Biomass burning for home energy use contributes to negative health outcomes and environmental degradation. As part of the REACCTING study (Research on Emissions, Air quality, Climate, and Cooking Technologies in Northern Ghana), personal exposure to ...
Ricardo Piedrahita, Evan R. Coffey, Yolanda Hagar, Ernest Kanyomse, Katelin Verploeg, Christine Wiedinmyer, Katherine L. Dickinson, Abraham Oduro, Michael P. Hannigan   +8 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source