Results 101 to 110 of about 915,369 (314)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
The selfie generation: a transformation of visual social relationships
Vista, 2019 The selfie generation is a term commonly used to describe people born after 1981 because of the supposed proliferation of selfies they take daily. If Selfies indeed define a generation of people, then they require close consideration as an evolution of ...
Fiona Andreallo
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Mapping the Implementation Practices of the 15-Minute City
Smart CitiesThis paper delves into the rapidly progressing 15-Minute City concept, an innovative urban planning model that envisions a city where residents can access essential services and amenities within a 15-min walk or bike ride from their homes. Endorsed by UN-
Zaheer Allam +4 more
doaj +1 more source
More Than Meets The Eye: Toward an Ontology of Proximity
Proceedings from the Document Academy, 2019 Words cannot describe photographs in the same sense that key words or subject headings can describe verbal documents because words are not native elements of photographs.
Laurie Bonnici, Brian O'Connor
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
DEMOGRAPHICS AND THE VALUE OF PARK PROXIMITY IN GREENVILLE, SOUTH CAROLINA [PDF]
The effect of proximity to different types of parks on housing prices is estimated using a unique data set of single family homes sold between 1990 and 1999 in Greenville, South Carolina.
Owusu-Edusei, Kwame, Espey, Molly
core +1 more source
Proximity and Gaze Influences Facial Temperature: A Thermal Infrared Imaging Study. [PDF]
, 2014 Direct gaze and interpersonal proximity are known to lead to changes in psycho-physiology, behaviour and brain function. We know little, however, about subtler facial reactions such as rise and fall in temperature, which may be sensitive to contextual ...
Marc Baker +17 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source