Results 81 to 90 of about 915,369 (314)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
CROSS-BORDER COOPERATION AND LOCAL DEVELOPMENT IN THE PYRENEES. THE CASE OF CERDANYA
European Journal of Geography, 2013 This paper examines how cross-border regions can generate, under certain preconditions and with EU support, territorial cooperation based on local endogenous development, reducing the effect of mental and physical borders as a potential new centrality ...
Matteo BERZI
doaj +2 more sources
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Studies of Proximity in Coworking Spaces: the Basic Conceptual Challenges
European Spatial Research and Policy, 2020 The article aims to identify main research challenges in studying coworking spaces (CSs) within the field of economic geography. It combines the perspective of proximity economics with the growing body of papers about spatial aspects of the operations of
Grzegorz Micek
doaj +1 more source
Proximity-Induced Superconductivity in CdTe–HgTe Core–Shell Nanowires [PDF]
, 2019 In this Letter we report on proximity superconductivity induced in CdTe–HgTe core–shell nanowires, a quasi-one-dimensional heterostructure of the topological insulator HgTe.
Christoph Brüne (6743186) +11 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Discourse disctance and the swahili demonstratives
Studies in African Linguistics, 1987 Proximity is the key concept for understanding a speaker's choice of Swahili demonstrative forms. The alternative approach in Leonard [1985] that proposes a speaker's concentration of attention as the key concept overlooks significant aspects of text ...
Timothy Wilt
doaj
Geography of Scientific Knowledge: A Proximity Approach [PDF]
The geography of scientific knowledge is defined as the replication process of locally produced knowledge claims. Proximity in social, cognitive, and physical dimensions promotes the sharing of tacit knowledge.
Koen Frenken
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source