Results 111 to 120 of about 2,364,493 (299)

Spectral Features of the Proximity Effect

, 1999
We calculate the local density of states (LDOS) of a superconductor-normal metal sandwich at arbitrary impurity concentration. The presence of the superconductor induces a gap in the normal metal spectrum that is proportional to the inverse of the ...
Altland, Belzig, C Bruder, Frahm, Golubov, Lodder, S Pilgram, Saint-James, Schomerus, W Belzig   +9 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Knowledge networks in the Dutch aviation industry: the proximity paradox [PDF]

The importance of geographical proximity for interaction and knowledge sharing has been discussed extensively in economic geography in recent years. There is increasing consensus that it is just one out of many types of proximities that might be relevant.
Ron Boschma, Tom Broekel
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Urbanization and Drivers for Dual Capital City: Assessment of Urban Planning Principles and Indicators for a ‘15-Minute City’

Land
Cities, particularly megacities, face significant challenges in transitioning toward sustainability. Many countries have developed dual or multiple capitals for diverse purposes (e.g., political, administrative, economic, touristic, and cultural ...
Mohsen Aboulnaga, Fatma Ashour, Maryam Elsharkawy, Elena Lucchi, Sarah Gamal, Aya Elmarakby, Shahenda Haggagy, Noureen Karar, Nourhan H. Khashaba, Ahmed Abouaiana   +9 more
doaj   +1 more source

Spillovers in Space: Does Geography Matter? [PDF]

We simultaneously assess the contributions to productivity of three sources of research and development spillovers: geographic, technology and product- market proximity.
John Van Reenen, Joris Pinkse, Margaret E. Slade, Sergey Lychagin   +3 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Metodologia de identificação de aglomerações produtivas locais

Nova Economia, 2006
The literature on industrial and regional economics is full of cases studies of local productive agglomerations. A significant part of the empirical studies on this subject have concentrated on the analysis of existing productive agglomerations.
Marco Crocco, Rangel Galinari, Fabiana Santos, Mauro Borges Lemos, Rodrigo Simões   +4 more
doaj  

Location, Proximity, and M&A Transactions [PDF]

, 2015
In this paper, we examine how the geographic location of firms affects acquisition decisions and value creation for acquirers in takeover transactions. We find that firms located in an urban area are more likely to receive a takeover bid and complete a ...
Cai, Ye, Tian, Xuan, Xia, Han
core   +1 more source