Results 61 to 70 of about 380,554 (266)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Location by Proxy

Journal of Philosophical Logic
Abstract The concept of location—of something being located at, or occupying, a region or a place—has been an important topic of philosophical investigation over the past fifteen years or so. Yet all the theories of location that have been put forward so far are unsatisfactory, because they fail to have the conceptual resources to describe ...
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

How does the magnetic gradient scale length influence complexity of filamentary coils in stellarators?

Nuclear Fusion
The distance between the last closed flux surface (LCFS) and the nearest electromagnetic coils is a dominating factor in the cost, size, and engineering difficulty of stellarators.
John Kappel, Matt Landreman, Philipp Jurašić, Sophia A. Henneberg   +3 more
doaj   +1 more source

The relationship between milk urea nitrogen content and urinary nitrogen excretion as determined in 4 Swiss dairy breeds

Journal of Dairy Science
: Ammonia (NH3) originating from agriculture substantially contributes to the environmental nitrogen load and threatens sensitive ecosystems by inducing eutrophication and acidification of the soil.
A. Burren, M. Terranova, M. Kreuzer, T. Kupper, S. Probst   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Underestimating Children’s Self-reported Pain: Agree/Disagree?

Turkish Journal of Anaesthesiology and Reanimation
Objective: To compare postoperative pain after different surgical types and grades using the visual analogue scale (VAS) and numeric rating scale (NRS) evaluated by the patient, parent, and nurse.
Şefika Başoğlu, Özlem Selvi Can, Volkan Baytaş, Hakan Yılmaz, Fatma Nur Erkent   +4 more
doaj   +1 more source

Utilization of the propensity score method: an exploratory comparison of proxy-completed to self-completed responses in the Medicare Health Outcomes Survey

Health and Quality of Life Outcomes, 2003
Background This research examined the use of the propensity score method to compare proxy-completed responses to self-completed responses in the first three baseline cohorts of the Medicare Health Outcomes Survey, administered in 1998, 1999, and 2000 ...
Drachman David, Shannon Erin, Fowler Brenda M, Cox Jacquilyn, Bannister Wade M, Ellis Beth, Adams Randall W, Giordano Laura A   +7 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Relationship between proxy behavior in clinic attendance and disease control among persons with hypertension and diabetes at a rural primary health center: A cohort analysis in South India

Journal of Family Medicine and Primary Care
Aims: Among persons with hypertension and diabetes on treatment for at least 1 year at the Rural Health Centre (RHC) noncommunicable disease (NCD) clinic, 1. To determine the control status for hypertension and diabetes. 2.
Viswanath Narendiran, Nishaant Ramasamy, Sonali Sarkar   +2 more
doaj   +1 more source