Results 41 to 50 of about 327,219 (245)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Agreement between child self-report and parent-proxy report for functioning in pediatric chronic pain

Journal of Patient-Reported Outcomes
Purpose Accurate assessment of chronic pain and functional disability in children and adolescents is imperative for guiding pain management interventions.
Joan W. Hanania, Jessica Edwards George, Christie Rizzo, Justin Manjourides, Laura Goldstein   +4 more
doaj   +1 more source

Metrics to quantify the degree of co-location of urban water infrastructure

Water Science and Technology
Co-located infrastructure networks such as road, water, and sewer in theory offer the possibility for integrated multi-infrastructure interventions. However, how closely these networks are aligned in space and time determines the practical extent to ...
Shamsuddin Daulat, Bardia Roghani, Jeroen Langeveld, Marius Møller Rokstad, Franz Tscheikner-Gratl   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Wiring optimization explanation in neuroscience: What is Special about it? [PDF]

, 2019
This paper examines the explanatory distinctness of wiring optimization models in neuroscience. Wiring optimization models aim to represent the organizational features of neural and brain systems as optimal (or near-optimal) solutions to wiring ...
Barberis, Sergio Daniel
core   +6 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evaluation of immunisation coverage for Aboriginal and Torres Strait Islander children using the Australian Childhood Immunisation Register

Australian and New Zealand Journal of Public Health, 2004
Objective: To estimate immunisation coverage for routinely administered vaccines among children using receipt of a particular Hib vaccine (PRP‐OMP) as a proxy for Indigenous status.
Brynley P. Hull, Peter B. McIntyre, Sophia Couzos   +2 more
doaj   +1 more source

Impact of telemonitoring approaches on integrated HIV and TB diagnosis and treatment interventions in sub-Saharan Africa: a scoping review [PDF]

Health Promotion Perspectives, 2017
Background: This paper explores telemonitoring approaches as a promising real time and contextual strategy in improving HIV and TB interventions, quality access and uptake, retention, adherence and coverage impact in endemic and epidemic prone-regions ...
Clarence S Yah, Ernest Tambo, Christopher Khayeka-Wandabwa, Jeanne Y. Ngogang   +3 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Indirect Interventions in Civil Wars: The Use of States as Proxies in Military Interventions

Czech Journal of International Relations, 2019
Current research on motivational sources of military interventions in civil wars frequently assumes that states intervene due to direct interests in the civil war country.
Klosek, Kamil
doaj