Results 31 to 40 of about 51,239 (287)

Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.

PLoS ONE, 2014
UnlabelledChronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD). (Pro)renin receptor (PRR) is activated in the kidney of CKD.
Maimaiti Yisireyili, Shinichi Saito, Shaniya Abudureyimu, Yelixiati Adelibieke, Hwee-Yeong Ng, Fuyuhiko Nishijima, Kyosuke Takeshita, Toyoaki Murohara, Toshimitsu Niwa   +8 more
doaj   +1 more source

Immunostimulatory activity of Paeonia lactiflora through TLR4-dependent activation of p38, JNK, and ERK1/2 in mouse macrophages, RAW264.7 cells

Food and Agricultural Immunology, 2023
Paeonia lactiflora (P. lactiflora) has been recently reported to increase the production of proinflammatory mediators and activates phagocytosis in macrophages.
Min Yeong Choi, So Jung Park, Jin Boo Jeong   +2 more
doaj   +1 more source

Effects of the (Pro)renin Receptor on Cardiac Remodeling and Function in a Rat Alcoholic Cardiomyopathy Model via the PRR-ERK1/2-NOX4 Pathway

Oxidative Medicine and Cellular Longevity, 2019
Alcoholic cardiomyopathy (ACM) caused by alcohol consumption manifests mainly as by maladaptive myocardial function, which eventually leads to heart failure and causes serious public health problems.
Xinran Cao, Shiran Yu, Yuanyuan Wang, Min Yang, J. Xiong, Haitao Yuan, Bo Dong   +6 more
semanticscholar   +1 more source

Deciphering the immunological and prognostic features of bladder cancer through platinum-resistance-related genes analysis and identifying potential therapeutic target P4HB

Frontiers in Immunology, 2023
ObjectivesTo identify the molecular subtypes and develop a scoring system for the tumor immune microenvironment (TIME) and prognostic features of bladder cancer (BLCA) based on the platinum-resistance-related (PRR) genes analysis while identifying P4HB ...
Situ Xiong, Situ Xiong, Sheng Li, Sheng Li, Jin Zeng, Jin Zeng, Jianqiang Nie, Jianqiang Nie, Taobin Liu, Taobin Liu, Xiaoqiang Liu, Luyao Chen, Bin Fu, Bin Fu, Jun Deng, Songhui Xu, Songhui Xu   +16 more
doaj   +1 more source

Commercial PRRS Modified-Live Virus Vaccines [PDF]

Vaccines, 2021
Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) presents one of the challenging viral pathogens in the global pork industry. PRRS is characterized by two distinct clinical presentations; reproductive failure in breeding animals (gilts, sows, and boars), and respiratory disease in growing pigs.
openaire   +3 more sources

Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses

Viruses, 2017
Modern vaccinology has increasingly focused on non-living vaccines, which are more stable than live-attenuated vaccines but often show limited immunogenicity.
Andri Vasou, N. Sultanoglu, S. Goodbourn, R. Randall, L. Kostrikis   +4 more
semanticscholar   +1 more source

Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. [PDF]

PLoS ONE, 2013
The role of the prorenin receptor (PRR) in the regulation of ureteric bud (UB) branching morphogenesis is unknown. Here, we investigated whether PRR acts specifically in the UB to regulate UB branching, kidney development and function.
Renfang Song, Graeme Preston, Atsuhiro Ichihara, Ihor V Yosypiv   +3 more
doaj   +1 more source

Metabolism of Paeoniae Radix Rubra and its 14 constituents in mice

Frontiers in Pharmacology, 2022
Objective: Paeoniae Radix Rubra (PRR) is a commonly used traditional Chinese medicine with the effects of clearing away heat, cooling the blood, and relieving blood stasis.
Jing Zhang, Yang Lv, Jing Zhang, Wen-Jin Shi, Xu-Yan Guo, Jing-Jing Xu, Peng-Pu Wang, Xue-Tai Chen, Lin-Han Xiang, Feng Xu, Xuan Wang, Shao-Qing Cai   +11 more
doaj   +1 more source

Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection

PLoS Pathogens, 2018
Shigella spp. are pathogenic bacteria that cause bacillary dysentery in humans by invading the colonic and rectal mucosa where they induce dramatic inflammation.
Valeria Ciancarella, L. Lembo-Fazio, Ida Paciello, Anna Bruno, S. Jaillon, S. Berardi, Marialuisa Barbagallo, S. Meron-Sudai, D. Cohen, A. Molinaro, G. Rossi, C. Garlanda, M. Bernardini   +12 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source