Results 71 to 80 of about 51,239 (287)

(Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway

Journal of Translational Medicine
Background (Pro)renin receptor (PRR) is highly expressed in renal tubules, which is involved in physiological and pathological processes. However, the role of PRR, expressed in renal tubular epithelial cells, in diabetic kidney disease (DKD) remain ...
Shiying Xie, Shicong Song, Sirui Liu, Qiong Li, Wei Zou, Jianting Ke, Cheng Wang   +6 more
doaj   +1 more source

Autophagy and the (pro)renin receptor

Frontiers in Endocrinology, 2013
The (pro)renin receptor (PRR) is a newly reported member of the renin-angiotensin system (RAS); a hormonal cascade responsible for regulating blood pressure.
Katrina Jean Binger, Dominik N Muller
doaj   +1 more source

Pseudo-Response Regulator (PRR) Homologues of the Moss Physcomitrella patens: Insights into the Evolution of the PRR Family in Land Plants

DNA Research, 2010
The pseudo-response regulators (PRRs) are the circadian clock component proteins in the model dicot Arabidopsis thaliana. They contain a receiver-like domain (RLD) similar to the receiver domains of the RRs in the His–Asp phosphorelay system, but the ...
S. Satbhai, T. Yamashino, Ryo Okada, Yuji Nomoto, T. Mizuno, Yuki Tezuka, Tomonori Itoh, Mitsuru Tomita, Susumu Otsuki, S. Aoki   +9 more
semanticscholar   +1 more source

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Advanced Science, EarlyView.
Wall‐associated receptor‐like kinases (WAKLs) play pivotal roles in extracellular–intracellular signal transduction. Upon sensing Verticillium dahliae infestation at the plasma membrane, GbWAKL20 accumulates and transmits signals to the nucleus via endoplasmic reticulum‐mediated Golgi vesicle transport.
Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo   +7 more
wiley   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, EarlyView.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Single cell analysis of human RAD18-dependent DNA post-replication repair by alkaline bromodeoxyuridine comet assay. [PDF]

PLoS ONE, 2013
Damage to DNA can block replication progression resulting in gaps in the newly synthesized DNA. Cells utilize a number of post-replication repair (PRR) mechanisms such as the RAD18 controlled translesion synthesis or template switching to overcome the ...
Mónika Mórocz, Himabindu Gali, István Raskó, C Stephen Downes, Lajos Haracska   +4 more
doaj   +1 more source

PRRs in pathogen recognition

Open Life Sciences, 2006
AbstractThe innate immune system provides the first line of host defense against invading microorganisms before the development of adaptive immune responses. Innate immune responses are initiated by germline-encoded pattern recognition receptors (PRRs), which recognize specific structures of microorganisms.
Uematsu Satoshi, Akira Shizuo
openaire   +2 more sources

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Chemical comparison of dried rehmannia root and prepared rehmannia root by UPLC-TOF MS and HPLC-ELSD with multivariate statistical analysis

Acta Pharmaceutica Sinica B, 2013
To identify the chemical differences which lead to the different therapeutic effects of dried rehmannia root (DRR) and prepared rehmannia root (PRR), we compared the chemical composition of decoctions of randomly purchased DRR and PRR using ultra ...
Qiande Liang, Jing Ma, Zengchun Ma, Yuguang Wang, Hongling Tan, Chengrong Xiao, Ming Liu, Beibei Lu, Boli Zhang, Yue Gao   +9 more
doaj   +1 more source

Parasitic Plant–Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies

Advanced Science, EarlyView.
Parasitic plants devastate global agriculture through sophisticated molecular interactions with host crops. This review synthesizes current understanding of parasitic plant‐host interactions, from strigolactone‐mediated germination and haustorium formation to host defense mechanisms.
Jiayang Shi, Qi Xie, Feifei Yu
wiley   +1 more source