Results 91 to 100 of about 46,972 (257)

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source

Chain‐End Grafting of RAFT Polyelectrolyte Macroligands to Stabilize Near‐Infrared‐Emitting Gold Nanoclusters

Macromolecular Rapid Communications, EarlyView.
Surface‐functionalized gold nanoclusters (AuNCs) are synthesized in situ by chain‐end grafting of RAFT polyelectrolytes at room temperature directly in water. It leads to highly stable polymer‐AuNCs nanohybrids emitting near‐infrared photoluminescence with µs lifetimes. ABSTRACT With their photoluminescence properties, gold nanoclusters (AuNCs, d<2 nm)
Bárbara Casteleiro, Pierre Alcouffe, Fernande Da Cruz, Agnès Crépet, José Manuel Gaspar Martinho, Marie‐Thérèse Charreyre, José Paulo Sequeira Farinha, Arnaud Favier   +7 more
wiley   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Current Status of Vaccines for Porcine Reproductive and Respiratory Syndrome: Interferon Response, Immunological Overview, and Future Prospects

Vaccines
Porcine reproductive and respiratory syndrome (PRRS) remains a formidable challenge for the global pig industry. Caused by PRRS virus (PRRSV), this disease primarily affects porcine reproductive and respiratory systems, undermining effective host ...
Jiuyi Li, Laura C. Miller, Yongming Sang
doaj   +1 more source

A PLP‐SEC Investigation of Di(Ethylene Glycol) Methyl Ether Methacrylate Radical Polymerization Propagation Kinetics in Solution

Macromolecular Reaction Engineering, EarlyView.
The propagation rate coefficient of di(ethylene glycol) methyl ether methacrylate exhibits the same temperature dependency but is a factor of 12 higher in aqueous solution compared to bulk. Smaller increases are observed in ethanol and ethanol/water mixtures, with the value of the rate coefficient decreasing as the monomer concentration in solution is ...
Fatemeh Salarhosseini, Robin A. Hutchinson   +1 more
wiley   +1 more source

Interdiction Models and Heuristics for Graph Propagation

Networks, EarlyView.
ABSTRACT Given a graph G=(V,E)$$ G=\left(V,E\right) $$ and a set S⊂V$$ S\subset V $$ of activated/infected nodes, we consider the problem of determining the set of c$$ c $$ nodes that minimizes the network propagation on the subgraph that results from the removal of those c$$ c $$ nodes. To measure network propagation, we assume that a node i$$ i $$ is
Agostinho Agra, José Maria Samuco
wiley   +1 more source

Evaluating the Evolving Real‐World Adverse Events of GLP‐1RAs Using FDA Adverse Event Reporting System (FAERS)

Obesity, EarlyView.
Web portal for interrogating Adverse Events of GLP‐1 RA in diabetes vs weight control/obesity. ABSTRACT Objective This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) using the US FDA Adverse Event Reporting System (FAERS).
David Stone, Mary Playdon, Stephen D. Hursting, Aik Choon Tan   +3 more
wiley   +1 more source

Photonic nanovoids for tailored optoelectronic response in silicon solar cells

Responsive Materials, EarlyView.
Optoelectronic workflow followed by experimental validation, demonstrating state‐of‐the‐art efficiency gains. Abstract As crystalline silicon (c‐Si) solar cells become thinner to reduce cost and weight, the optical design principles that govern light trapping (LT) must evolve.
Ivan M. Santos, Miguel Alexandre, Valentin D. Mihailetchi, Kezheng Li, António T. Vicente, Eva Almeida, Mónica Dyreby, Tiago Mateus, Tomás Calmeiro, Elvira Fortunato, Rodrigo Martins, Hugo Águas, Manuel J. Mendes   +12 more
wiley   +1 more source