Results 11 to 20 of about 829 (131)

Nonlinearity and Temporal Dependence [PDF]

Nonlinearities in the drift and diffusion coefficients influence temporal dependence in scalar diffusion models. We study this link using two notions of temporal dependence: beta-mixing and rho-mixing.
Lars P. Hansen, Marine Carrasco, Xiaohong Chen   +2 more
core   +6 more sources

Evolution of flower color pattern through selection on regulatory small RNAs [PDF]

, 2017
Small RNAs (sRNAs) regulate genes in plants and animals. Here, we show that population-wide differences in color patterns in snapdragon flowers are caused by an inverted duplication that generates sRNAs.
Bradley, Desmond, Carpenter, Rosemary, Coen, Enrico, Copsey, Lucy, Couchman, Matthew, Dalmay, Tamas, Field, David, Li, Miaomiao, Li, Qun, Mohorianu, Irina-Ioana, Tavares, Hugo, Whibley, Annabel, Xu, Ping, Xue, Yongbiao   +13 more
core   +1 more source

Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes [PDF]

, 2016
It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV.
Akonkwa, DBM, Akoua-Koffi, C, Bergl, RA, Boesch, C, Calvignac-Spencer, S, Eckardt, W, Ehlers, B, Fruth, B, Gillespie, TR, Gray, M, Hohmann, G, Karhemere, S, Kujirakwinja, D, Langergraber, K, Leendertz, FH, Madinda, NF, Muyembe, J-J, Nishuli, R, Pauly, M, Peeters, M, Petrzelkova, KJ, Robbins, MM, Schubert, G, Stoinski, TS, Todd, A, Wertheim, JO, Wittig, RM, Zuberbuhler, K   +27 more
core   +2 more sources

Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans [PDF]

, 2018
It has long been suspected that the rate of mutation varies across the human genome at a large scale based on the divergence between humans and other species.
A Eyre-Walker, A Eyre-Walker, A Eyre-Walker, A Eyre-Walker, A Hodgkinson, A Hodgkinson, A Kong, A Kong, Adam Eyre-Walker, B Arbeithuber, B Paten, B Schuster-Bockler, C Seoighe, C TEP, DF Conrad, DL Bodian, E Kenigsberg, F Chiaromonte, F Pratto, F Supek, G Bernardi, G Bernardi, G McVicker, GP Holmquist, H Jonsson, I Hellmann, I Hellmann, J Filipski, J Filipski, J Meunier, JB Haldane, JC Dohm, JJ Cai, JJ Michaelson, K Harris, K Harris, K Wolfe, KE Lohmueller, KH Wolfe, L Duret, L Duret, LC Francioli, M Blanchette, MJ Lercher, MW Nachman, NV Terekhanova, P Moorjani, P Polak, Peter F. Arndt, R Burgess, RE Thurman, RS Hansen, S Besenbacher, S Glemin, S Katzman, S Tyekucheva, Shamil R. Sunyaev, Thomas C. A. Smith, TI Gossmann, TN Phung, V Aggarwala, VM Schaibley, WS Wong, Y Benjamini, YH Woo   +64 more
core   +4 more sources

A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity [PDF]

, 2014
The timely delivery of membranous organelles and macromolecules to specific locations within the majority of eukaryotic cells depends on microtubule-based transport.
Abenza JF, Anthony J. Roberts, Bailleul B, Barbour L, Cho C, Eckley DM, Egan MJ, Egan MJ, Erzberger JP, Fernandez-Abalos JM, Galagan J, Gero Steinberg, Gibson DG, Hammer JA, Hendricks AG, Huang J, Ikenaga M, Imamula K, Kaeling Tan, Kon T, Laan L, Lee SB, Lefrancois P, Lenz JH, Li H, Li H, Ligon LA, Malone CJ, Mark Chonofsky, Martin J. Egan, McKenna A, Meyer M, Morris NR, Murakami K, Nayak T, Orr-Weaver TL, Perlson E, Qiu W, Reck-Peterson SL, Requena N, Samara L. Reck-Peterson, Schafer DA, Schmidt H, Seidel C, Shaner NC, Sivagurunathan S, Subach OM, Szewczyk E, Todd RB, Todd RB, Vogel SK, Wortman JR, Xiang X, Xiang X, Zhang J, Zhang J   +55 more
core   +3 more sources

Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates [PDF]

, 2023
SLC22A10 is classified as an orphan transporter with unknown substrates and function. Here we describe the discovery of the substrate specificity and functional characteristics of SLC22A10.
Alentorn, Pol, Artegoitia, Virginia M, Artursson, Per, Brand, Colin M, Capra, John A, Ceylan, Merve, Chien, Huan-Chieh, Dainat, Jacques, Ferrández-Peral, Luis, Fontsere, Claudia, Giacomini, Kathleen M, Handin, Niklas, Koleske, Megan L, Lara, Giovanni, Marques-Bonet, Tomas, Newman, John W, Sali, Andrej, Yee, Sook Wah, Zalevsky, Arthur, Zhou, Xujia   +19 more
core   +1 more source

The impact of ancestral population size and incomplete lineage sorting on Bayesian estimation of species divergence times [PDF]

, 2015
MdR was supported by Biotechnology and Biological Sciences Research Council (UK) grant BB/J009709/1 awarded to ...
Angelis, K, Dos Reis, M
core   +1 more source

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein [PDF]

, 2023
The transcription factor forkhead box P2 (FOXP2) is involved in the development of language and speech in humans. Two amino acid substitutions (T303N, N325S) occurred in the human FOXP2 after the divergence from the chimpanzee lineage.
Bornschein Ulrich, Enard Wolfgang, Hevers Wulf, Pääbo Svante, Zeberg Hugo   +4 more
core   +1 more source

Resurrecting the Dead (Molecules) [PDF]

, 2017
Biological molecules, like organisms themselves, are subject to genetic drift and may even become “extinct”. Molecules that are no longer extant in living systems are of high interest for several reasons including insight into how existing life forms ...
Heddle, Jonathan, Zaucha, Jan
core   +4 more sources

In‐situ‐Konstruktion von Imidazopyridinium‐Fluoreszenzlabels für Biokonjugationen

Angewandte Chemie, EarlyView.
Durch Chromophor‐Engineering von Isochinolinaldehyden entstehen TICT‐basierte fluorogene Farbstoffe für die In Situ Markierung unterschiedlicher (Bio‐)Moleküle mit großen Stokes‐Verschiebungen, die mit der Zellbildgebung kompatibel sind. ZUSAMMENFASSUNG Einfache, effiziente Transformationen fluorogenen Charakters, die unter biokompatiblen Bedingungen ...
Dongchen Du, László Albert, Milan Weitzel, Linda E. Eijsink, Elena R. Cotroneo, Dennis Marzin, Felipe Opazo, Nadja A. Simeth   +7 more
wiley   +1 more source