Results 21 to 30 of about 829 (131)

Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome. [PDF]

, 2014
yesEpigenetic information is available from contemporary organisms, but is difficult to track back in evolutionary time. Here, we show that genome-wide epigenetic information can be gathered directly from next-generation sequence reads of DNA isolated ...
Andersson, R., Gilbert, Thomas, Hoover, C., Jones, P., Kelly, T., Krogh, A., Lilje, B., Lindgreen, S., Orlando, L., Parker, B., Pedersen, J., Prokhortchouk, E., Rasmussen, M., Rubin, E., Sandelin, A., Tikhonov, A., Tobin, D., Valen, E., Vang, S., Velazquez, A., Willerslev, E.   +20 more
core   +2 more sources

Simultaneous precise editing of multiple genes in human cells

, 2019
. When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results ...
Chintalapati, M., Kanis, P., Macak, D., Maricic, T., Pääbo, S., Riesenberg, S.   +5 more
core   +1 more source

Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement. [PDF]

, 2015
Viruses in the family Luteoviridae have positive-sense RNA genomes of around 5.2 to 6.3 kb, and they are limited to the phloem in infected plants. The Luteovirus and Polerovirus genera include all but one virus in the Luteoviridae.
Brault, Véronique, Chung, Betty, Firth, Andrew, Miller, W. Allen, Miller, W. Allen, Rakotondrafara, Aurélie, Reinbold, Catherine, Scheidecker, Danièle, Smirnova, Ekaterina, Ziegler-Graff, Véronique   +9 more
core   +9 more sources

Detecting cryptic ghost lineage introgression in four‐taxon genomic datasets

Applications in Plant Sciences, EarlyView.
Abstract Premise Hybridization and introgression are pervasive evolutionary forces that have played fundamental roles in shaping the diversity of wild and domesticated plants. Four‐taxon tests for introgression provide a reliable framework for detecting signatures of ancient introgression from genomic data, which have played an important role in ...
Evan S. Forsythe, Blaine S. Pappa, Darren A. Clavette, Devin Y. Mendoza   +3 more
wiley   +1 more source

Exact Solutions for the Moving Firefighter Problem on Trees

Networks, EarlyView.
ABSTRACT The moving firefighter problem (MFP) is a more realistic variant of the classic firefighter problem (FP), where firefighters require time for both travel and defense. Unfortunately, the only known exact solution for the MFP does not scale. In this paper, we establish that the MFP is NP‐complete on trees of maximum degree three and present four
Mauro A. Montenegro‐Meza, Uriel Corona‐Bermúdez, Rolando Menchaca‐Méndez, Ricardo Menchaca‐Méndez, José Alejandro Cornejo‐Acosta   +4 more
wiley   +1 more source

Prufer substitutions on a coupled system involving the p-Laplacian

Electronic Journal of Differential Equations, 2013
In this article, we employ a modified Prufer substitution acting on a coupled system involving one-dimensional $p$-Laplacian equations. The basic properties for the initial valued problem and some estimates are obtained.
Wei-Chuan Wang
doaj  

Out in the cold? A review of Early Middle Palaeolithic settlements in northern Central Europe, age data and geological preconditions for site formation and preservation

Boreas, EarlyView.
The characteristics of settlement of Neanderthals in northern Central Europe during the earlier phases of the Middle Palaeolithic (Marine Isotope Stage 8–6) have been a matter of debate for decades, specifically regarding the population dynamics at such latitudes during the coldest phases. In this paper, we review the known archaeological record of the
Gianpiero Di Maida, Jutta Winsemann, Malte Hoffmann, Tobias Lauer, Utz Böhner, Thomas Terberger   +5 more
wiley   +1 more source

Nodal properties for p-Laplacian systems

Electronic Journal of Differential Equations, 2017
We consider a system of differential equations involving the p-Laplacian. We prove the existence of oscillatory solutions with prescribed numbers of zeros, and show that the solutions satisfy the Dirichlet boundary conditions when the large parameters
Yan-Hsiou Cheng, Wei-Chuan Wang
doaj  

The Internet and the Project of Communications Law [PDF]

, 2007
The internet offers the potential for economic growth stemming from online human communications, but recent industry and government actions have disfavored these possibilities by treating the internet like a content-delivery supply chain.
Crawford, Susan P.
core   +2 more sources

The Goldilocks Effect: How the “Just Right” Writing Styles of Global Corporate Responsibility Frameworks Shapes Their Use by Businesses

Regulation &Governance, EarlyView.
ABSTRACT The 21st century has witnessed a surge in the number of global corporate responsibility (GCR) frameworks issued by international organizations (IOs). Our study investigates whether and to what extent these frameworks shape businesses' Corporate Social Responsibility (CSR) communications.
Adam William Chalmers, Robyn Klingler‐Vidra   +1 more
wiley   +1 more source