Results 21 to 30 of about 46,483 (270)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

\u3cem\u3eFantassin: pour mon pays, la gloire et… des prunes\u3c/em\u3e by Charly Forbes [Review] [PDF]

open access: yes, 2012
Review of Charly Forbes, Fantassin: pour mon pays, la gloire et… des prunes.
Drolet, Gil
core   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

open access: yesFEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Recent Advances in the Bioactive Compounds of Prunes (Prunus domestica L.) and Their Health Benefits

open access: yesFood Frontiers
Prunes (Prunus domestica L.) are increasingly recognized for their multifaceted health benefits, which are derived from their rich bioactive compounds.
Luyang Han   +10 more
doaj   +1 more source

EFFECT OF TEMPERATURE ON THE PHYSICAL CHANGES AND DRYING KINETICS IN PLUM (Prunus domestica L.) POŽEGAČA VARIETY [PDF]

open access: yesChemical Industry and Chemical Engineering Quarterly, 2011
In this study, drying kinetics of autochthonous variety Požegača plum was examined in a laboratory dryer at three temperatures. The whole plum fruits, together with the kernels were subjected to the drying process.
Miloš Nikolić   +5 more
doaj  

Distilled Gradual Pruning With Pruned Fine-Tuning

open access: yesIEEE Transactions on Artificial Intelligence
Neural networks (NNs) have been driving machine learning progress in recent years, but their larger models present challenges in resource-limited environments. Weight pruning reduces the computational demand, often with performance degradation and long training procedures.
Federico Fontana   +6 more
openaire   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Detection of Cumulative Bruising in Prunes Using Vis–NIR Spectroscopy and Machine Learning: A Nonlinear Spectral Response Approach

open access: yesApplied Sciences
Early and accurate detection of mechanical damage in prunes is crucial for preserving postharvest quality and enabling automated sorting. This study proposes a practical and reproducible method for identifying cumulative bruising in prunes using visible ...
Lisi Lai, Hui Zhang, Jiahui Gu, Long Wen
doaj   +1 more source

The role of dietary fiber in the correction of digestion and constipation of various etiologies

open access: yesМедицинский совет, 2019
Psyllium is a predominantly soluble fiber among other natural plant-based dietary fiber used in food and pharmaceuticals and is sold as a laxative fiber. Isphagula (lat.
E. Yu. Plotnikova   +3 more
doaj   +1 more source

Designing optimal low-thrust gravity-assist trajectories using space-pruning and a multi-objective approach [PDF]

open access: yes, 2009
A multi-objective problem is addressed consisting of finding optimal low-thrust gravity-assist trajectories for interplanetary and orbital transfers. For this, recently developed pruning techniques for incremental search space reduction - which will be ...
Delinitz, M.   +4 more
core   +1 more source

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