Results 181 to 190 of about 377,372 (346)

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

open access: yesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou   +6 more
wiley   +1 more source

DarwinLM: Evolutionary Structured Pruning of Large Language Models [PDF]

open access: green
Shengkun Tang   +4 more
openalex   +1 more source

Mapping the Mistreatment Landscape: An Integrative Review and Reconciliation of Workplace Mistreatment Constructs

open access: yesJournal of Organizational Behavior, EarlyView.
ABSTRACT As the literature on workplace mistreatment has grown, so too have the number of constructs proposed to represent distinctive forms of mistreatment. However, considerable disagreement exists surrounding whether these proposed constructs represent unique manifestations of workplace mistreatment or represent a single underlying phenomenon.
Lindsay Y. Dhanani, Sean M. Bogart
wiley   +1 more source

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