Results 161 to 170 of about 299,242 (277)

Spatial heterogeneity in microglia-complement crosstalk: Implications for synaptic pruning in Alzheimer's disease. [PDF]

Alzheimers Dement
Ye Q, Gao W, Feng J, Li X, Li J, Yang F, Li L, Zi M, Wu X, Gao H, Li H.   +10 more
europepmc   +1 more source

Transdiagnostic symptom networks in adolescent psychopathology: A longitudinal panel network analysis

JCPP Advances, EarlyView.
Abstract Background Understanding symptom patterns of emerging psychopathology is essential for early detection and intervention. Network analysis offers a promising approach by conceptualizing emerging psychopathology as dynamic interactions between symptoms over time.
Xenia A. Häfeli, Larisa Morosan, Anja Hirsig, Stefanie J. Schmidt   +3 more
wiley   +1 more source

Variant selection to maximize variance explained in cis-Mendelian randomization. [PDF]

HGG Adv
Zhou A, Karhunen V, Tian H, Pott J, Patel A, Slob EAW, Burgess S.   +6 more
europepmc   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Viral modulation of synaptic pruning: implications for neuropathology and brain function. [PDF]

J Virol
Aliakbari S, Asadi S, Sayyah M, Naderi N, Salarvandian S, Khodagholi F, Gholami Pourbadie H.   +6 more
europepmc   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Learning Covariate Relations in Disease Progression Models Using Symbolic Neural Networks. [PDF]

CPT Pharmacometrics Syst Pharmacol
Sundell J, Wahlquist Y, Kjellsson MC, Karlsson MO, Soltesz K.   +4 more
europepmc   +1 more source

ParaHox Genes Revisited: From Gut Patterning to Integrated Axial and Neural Organization in Rotifera

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In rotifers, ParaHox genes show a dispersed genomic organization, with Xlox absent across gnathiferans. Exclusive neuronal expression of Gsx and Cdx reveals that ancestral ParaHox genes coordinated neural and epithelial development beyond gut patterning, suggesting an integrated role in early bilaterian body plan organization.
Andreas C. Fröbius, David B. Mark Welch, Holger Herlyn   +2 more
wiley   +1 more source

MAAR-Net: Multi-scale attention-assisted residual neural network for renal microvascular structure segmentation. [PDF]

PLoS One
Wang T, Lin B, Jiang T, Wang H, Yang D, Shang F, Li L, Li Y, Zhao M, Xu Y, Yan Y.   +10 more
europepmc   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source