Results 91 to 100 of about 132,704 (355)

Real‐world efficacy and toxicity of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma according to IMDC risk criteria—A multi‐center retrospective analysis on behalf of the GUARDIANS group

International Journal of Cancer, EarlyView.
What's New? The combination of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma has demonstrated durable response and tolerability in clinical trials. However, inclusion criteria for clinical studies are restrictive, and patients in the real‐world setting tend to have more comorbidities.
Hendrik Dinkel, Linus Materna, Ramona Stelmach, Stefanie Zschäbitz, Stephanie Neuberger, Can D. Aydogdu, Jozefina Casuscelli, Timo Egenolf, Matteo Silberg, Julie Steinestel, Arne Strauss, Florian Kirchhoff, Marit Ahrens, Pia Paffenholz, Richard Cathomas, Berna C. Özdemir, Christopher Gossler, Philipp Ivanyi, Marc Rehlinghaus, Thomas Hilser, Viktor Grünwald, Katrin Schlack   +21 more
wiley   +1 more source

Metabolomic analysis of uremic pruritus in patients on hemodialysis.

PLoS ONE, 2021
Pruritus is a common debilitating symptom experienced by hemodialysis patients. Treatment is difficult because the cause of uremic pruritus is not known. This study addressed the hypothesis that pruritus is caused by solutes that accumulate in the plasma
Christian G Bolanos, Nhat M Pham, Robert D Mair, Timothy W Meyer, Tammy L Sirich   +4 more
doaj   +1 more source

Maralixibat for the treatment of severe xanthomas in two children with Alagille syndrome: Case reports

JPGN Reports, EarlyView.
Abstract Alagille syndrome (ALGS) is a rare, autosomal dominant disorder which presents with a broad range of clinical manifestations, including cholestatic pruritus. A unique manifestation of ALGS is the presence of xanthomas in 24%–42% of patients, which can lead to liver transplantation.
Geetanjali Bora, Ruben E. Quiros‐Tejeira, Bernadette Vitola   +2 more
wiley   +1 more source

Secukinumab Reduces Psoriasis-associated Pruritus and Regenerates the Cutaneous Nerve Architecture: Results from PSORITUS a Doubleblind, Placebo-controlled, Randomized Withdrawal Phase IIIb Study

Acta Dermato-Venereologica
The occurrence of pruritus in psoriasis was previously underestimated but is a significant burden. Secukinumab (SEC), a monoclonal anti-interleukin-17A antibody, efficiently controls signs of psoriasis, but the effect on pruritus and cutaneous ...
Lina Renkhold, Manuel P. Pereira, Karin Loser, Dieter Metze, Daniel Baeumer, Nima Melzer, Maximilian Reinhardt, Athanasios Tsianakas, Thomas Luger, Christian Mess, Ruth Becker, Clara Hambüchen, Konstantin Agelopoulos, Sonja Ständer   +13 more
doaj   +1 more source

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris in a preadolescent population. [PDF]

, 2019
BackgroundAcne vulgaris (acne) is a common skin condition in children and adolescents. Efficacy of tretinoin is well documented in studies that included pediatric patients (12-18 years of age). With acne routinely presenting in younger patients, data are
Bhatt, Varsha, Eichenfield, Lawrence F, Guenin, Eric, Harris, Susan, Sugarman, Jeffrey L   +4 more
core   +1 more source

Brazilian Society of Surgical Oncology: Guidelines and Consensus Statement for Palliative Surgery in Oncology

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objective Palliative surgery in oncology aims to relieve symptoms, improve quality of life, and respect patient autonomy in advanced cancer. This study aimed to develop evidence‐based recommendations for safely indicating and performing palliative surgeries in Brazil, considering clinical, ethical, and multidisciplinary aspects.
Audrey Cabral Ferreira de Oliveira, Jordana Henz Hammes, Isabela Maria Alves de Almeida Oliva, Lara Andrade Mendes Mangieri, Ronald Enrique Delgado Bocanegra, Marcos Gonçalves Adriano Junior, Ana Caroline Fonseca Alves, Eliel Oliveira de Araujo, Jairo Cerqueira de Almeida Teixeira, Patricia Isabel Bahia Mendes Freire, Larissa de Jesus Almeida, Raquel Lacerda Dantas de Farias, Heládio Feitosa e Castro Neto, Alexandre Ferreira Oliveira, Reitan Ribeiro, Rodrigo Nascimento Pinheiro   +15 more
wiley   +1 more source

Evidences for gestures associated with pruritus in very young infants: a pilot study

Scientific Reports
The anatomical and functional basis for pruritus is present from birth. However, pruritus in this population is largely underestimated. The aim of this study was to analyze behaviors potentially associated with pruritus in infants under 6 months ...
Adrien Boyard, Camille Cosnard, David Simon, Camille Le Pors, Claire Abasq-Thomas, Marine Grandgeorge, Laurent Misery, Séverine Henry, Jean-Michel Roué   +8 more
doaj   +1 more source

Safety of Baricitinib for the Treatment of Atopic Dermatitis in Adults Over a Median of 1.6 and up to 4.6 Years Treatment: Final Integrated Analysis of Eight Clinical Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Baricitinib is a selective Janus kinase (JAK)1/JAK2 inhibitor approved in more than 70 countries for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults, and in over 30 countries for adolescents and children from age 2 years with moderate‐to‐severe AD, who are candidates for systemic therapy.
Antonio Costanzo, Antonio Torrelo, Eric L. Simpson, Marjolein De Bruin‐Weller, Diamant Thaçi, Norito Katoh, Silvia Sabatino, Andrew Buchanan, Kasia Morawska, Samuel Ogwu, Karen Denning, Jonathan I. Silverberg   +11 more
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients

International Journal of Nephrology, 2012
Background. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus. Methods.
Mansor Shakiba, Hoshang Sanadgol, Hamid Reza Azmoude, Mohamad Ali Mashhadi, Hassan Sharifi   +4 more
doaj   +1 more source