Results 61 to 70 of about 119,934 (290)
Acta Dermato-Venereologica, 2019 Central sensitization induces pain augmentation in chronic pain states. An analogous mechanism is speculated for chronic pruritus. This study compared patients with chronic pruritus (n = 79) of different origins (atopic dermatitis, chronic pruritus on ...
Manuel P. Pereira +5 more
doaj +1 more source
A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty [PDF]
, 2016 We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing ...
Anderson, K. +7 more
core +1 more source
ChemMedChem, Accepted Article.Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore +5 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract The aim of this study was to evaluate the bioequivalence and safety of a single application of crisaborole ointment to test formulation and reference formulation in healthy subjects under fasting conditions. A total of 32 subjects were included and divided into 2 groups (test‐reference; reference‐test).
Yanchao Wang +9 more
wiley +1 more source
Self-reported generalised pruritus among community-dwelling older adults in Malaysia
BMC Geriatrics, 2020 Background The ageing skin is more susceptible to pruritic dermatoses, which are associated with adverse psychosocial effects and reduced quality of life among older adults.
Shin Shen Yong +8 more
doaj +1 more source
Conditioned place preference reveals ongoing pain in calves 3 weeks after disbudding. [PDF]
, 2020 Hot-iron disbudding, a routine procedure that prevents horn bud growth through cauterization, is painful for calves. The resulting burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non-evoked pain.
Adcock, Sarah JJ, Tucker, Cassandra B
core
Clinical Pharmacology in Drug Development, EarlyView.Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano +8 more
wiley +1 more source
Metabolomic analysis of uremic pruritus in patients on hemodialysis.
PLoS ONE, 2021 Pruritus is a common debilitating symptom experienced by hemodialysis patients. Treatment is difficult because the cause of uremic pruritus is not known. This study addressed the hypothesis that pruritus is caused by solutes that accumulate in the plasma
Christian G Bolanos +4 more
doaj +1 more source
Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families. [PDF]
, 2018 IntroductionThe impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301 ...
Boguniewicz, Mark +7 more
core +2 more sources
Epilepsia Open, EarlyView.Abstract Objective To evaluate the effects of personalized multichannel tDCS on seizure frequency, severity, quality of life, and psychiatric comorbidities in patients with drug‐resistant focal epilepsy. Secondary goals include assessing the safety and feasibility of this approach.
Fabrice Bartolomei +12 more
wiley +1 more source