Results 51 to 60 of about 4,474 (234)

Chronic Pruritus [PDF]

, 2014
O Prurido crónico é um sintoma que tem um impacto significativo na qualidade de vida dos doentes. Pode estar associado a um vasto conjunto de doenças e na maioria dos casos, é difícil conseguir um alívio completo da sintomatologia. A investigação da sua
Amaro, C, Brás, S, Cardoso, J
core  

First Report of Homozygous COL7A1 c.5756delG Mutation Causing Recessive Dystrophic Epidermolysis Bullosa in a Non‐Consanguineous Japanese Family

JEADV Clinical Practice, EarlyView.
ABSTRACT Severe recessive dystrophic epidermolysis bullosa (RDEB) is usually caused by biallelic loss‐of‐function mutations in COL7A1. While the c.5756delG variant has been previously reported in heterozygous form, its clinical impact in homozygosity has not been described.
Nozomi Kohama, Sayaka Yamaguchi, Teruki Yanagi, Yumi Akamine, Kimiko Nonaka, Daisuke Utsumi, Kenzo Takahashi   +6 more
wiley   +1 more source

Role of Lasers in Anal Fistula Repair

Indian Journal of Colo-Rectal Surgery
An anal fistula is described as an external abnormal anatomical connection between the anorectal canal and the perianal skin. The incidence of anal fistulas is reported to be 5.6 and 12.3 per 100,000 in women and men, respectively.
Sajeet Nayar, Milind Mukund Joshi, Qaisar Jamal, Pankaj Sareen, Ravi Sharma, Vaibhav Kapoor   +5 more
doaj   +1 more source

A Case of Pembrolizumab‐Induced Pityriasis Lichenoides‐Like Eruption Treated Successfully With Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Immune‐checkpoint inhibitors (ICIs) have revolutionised melanoma treatment but can often cause severe and long‐standing cutaneous immune‐related adverse events (cirAEs). We report a case of refractory pembrolizumab‐induced pityriasis lichenoides (PL)‐like eruption successfully treated with dupilumab, leading to rapid and sustained remission ...
Evangelos Christou, Sharon Edwards, Andrew Affleck   +2 more
wiley   +1 more source

Effect of Gabapentin on Morphine Consumption and Pain after Surgical Debridement of Burn Wounds:A Double-Blind Randomized Clinical Trial Study [PDF]

, 2012
Background: Burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself.
Emir Alavi, C., Kavoosi, S., Koochakinejad, L., Rimaz, S., Sedighinejad, A., Tolouie, M.   +5 more
core   +1 more source

Response to Oral Dapsone in a Patient With Generalised Junctional Epidermolysis Bullosa

JEADV Clinical Practice, EarlyView.
ABSTRACT Dapsone is a potent antibacterial agent used as a first‐line treatment for leprosy and employed also as an anti‐inflammatory agent. Additionally, dapsone is used for a variety of other cutaneous conditions. Herein, we report a case of intermediate junctional epidermolysis bullosa that improved significantly with oral 4,4’‐diamino‐diphenyl ...
Shiho Mori, Manabu Fujimoto, Katsuto Tamai   +2 more
wiley   +1 more source

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors. [PDF]

, 2019
Purpose:To evaluate the safety, recommended phase II dose (RP2D) and efficacy of pexidartinib, a colony stimulating factor receptor 1 (CSF-1R) inhibitor, in combination with weekly paclitaxel in patients with advanced solid tumors.
Coussens, Lisa M, Dowlati, Afshin, Karlin, David A, Le, Mai H, Marimuthu, Adhirai, Peck, Alexandra, Reebel, Laura, Rodal, Mary Beth, Rugo, Hope S, Severson, Paul, Sharma, Neelesh, Wesolowski, Robert, West, Brian L   +12 more
core  

Assessing the Effect of Adalimumab in Granuloma Annulare: A Case Series and Literature Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Granuloma annulare (GA) is a benign granulomatous skin disorder for which standardized treatment guidelines are lacking due to limited evidence. Adalimumab, a TNF‐α inhibitor, shows promise as a therapeutic option due to its potential to disrupt GA granulomas.
Adriana Caixinha Valorenzos, Line Kibsgaard, Trine Bertelsen   +2 more
wiley   +1 more source

Prescribing practices of primary-care veterinary practitioners in dogs diagnosed with bacterial pyoderma [PDF]

, 2014
Concern has been raised regarding the potential contributions of veterinary antimicrobial use to increasing levels of resistance in bacteria critically important to human health.
A Hillier, A Mateus, A Wayne, AD Radford, AD Watson, Anke Hendricks, B Kirkwood, C Noli, CP Murphy, David C Brodbelt, DL Wells, DW Scott, DW Scott, EJ Pleydell, EM Lund, FC Tenover, IS Mason, J Bannoehr, J Cd, Jennifer F Summers, JF Summers, JR Fitzgerald, JS Weese, K Gortel, K Odensvik, L Beco, L Beco, LA Hughes, LM Freeman, LS Barter, M Escher, M Rantala, N Murayama, National Organisation of Animal Health (Great Britain) (NOAH), OM Briggs, PB Hill, PB Hill, PJ Ihrke, RK Anderson, T Sasaki, VJ Adams, WM Sischo   +41 more
core   +2 more sources

Successful Use of Bimekizumab in Refractory Acute Generalised Exanthematous Pustulosis Triggered by Amoxicillin‐Clavulanate

JEADV Clinical Practice, EarlyView.
ABSTRACT Acute generalised exanthematous pustulosis (AGEP) is a rare, acute neutrophilic dermatosis most commonly triggered by drugs, which typically resolves within 2 weeks following withdrawal of the causative agent. Topical and systemic corticosteroids remain the standard treatment.
Alexandra Junge, Charlotte Vogel, Theresa Hempel, Basil Signer, Nikhil Yawalkar, Kristine Heidemeyer   +5 more
wiley   +1 more source