Results 1 to 10 of about 80,471 (219)

Omadacycline versus moxifloxacin for community-acquired bacterial pneumonia (OPTIC-2): a phase 3b, randomised, double-blind, multicentre, controlled, noninferiority trialResearch in context [PDF]

open access: yesEClinicalMedicine
Summary: Background: Omadacycline is a first-in-class aminomethylcycline antibiotic approved to treat adults with community-acquired bacterial pneumonia (CABP).
Thomas M. File, Jr.   +12 more
doaj   +2 more sources

Alman Siyasi Birliğine Giden Süreçte Prusya’nın, Zollverein’ın ve Bismarck’ın Rolü

open access: yesAkademik İncelemeler Dergisi, 2023
Tarihi süreçte Avusturya gibi Kutsal Roma Germen İmparatorluğu ve Alman Konfederasyonu bünyesinde yer alan Prusya, Bismarck önderliğinde 1871’de Alman İmparatorluğu’nu ilan etmiştir.
Mehmet Öztürk
doaj   +1 more source

UNION OF THE ROMANIAN PRINCIPALITIES AND THE COLLECTIVE GUARANTEE OF THE EUROPEAN POWERS [PDF]

open access: yesAnnals: Series on History and Archaeology (Academy of Romanian Scientists), 2022
This study reveals a very specific issue in the field of the international relations history. As a matter of fact, the Romanian State՚s emergency presupposed an international regime exposed through the joint guarantee of the European Great Powers, as ...
Gheorghe CLIVETI
doaj   +1 more source

Omadacycline vs moxifloxacin in adults with community-acquired bacterial pneumonia

open access: yesInternational Journal of Infectious Diseases, 2021
Objective: Community-acquired bacterial pneumonia (CABP) is a major clinical burden worldwide. In the phase III OPTIC study (NCT02531438) in CABP, omadacycline was found to be non-inferior to moxifloxacin for investigator-assessed clinical response (IACR)
Antoni Torres   +9 more
doaj   +1 more source

Activity of omadacycline in vitro against Clostridioides difficile and preliminary efficacy assessment in a hamster model of C. difficile-associated diarrhoea

open access: yesJournal of Global Antimicrobial Resistance, 2022
: Objectives: Antibiotics are associated with increased risk of Clostridioides difficile infection, which has limited treatment options. We assessed in vitro activity of omadacycline (an aminomethylcycline antibiotic) against the C.
Raina Gay Leahy   +4 more
doaj   +1 more source

Die Domkapitel von Kurland und Riga. Ein Beitrag zum Inkorporationsbegriff im Deutschen Orden

open access: yesZeitschrift für Ostmitteleuropa-Forschung, 2023
Research on the cathedral chapters of the ecclesiastical province of Riga shows that the Teu-tonic Order played a significant role in how they operated, since five of the eight cathedral chapters were regulated according to its rule.
Johannes Götz
doaj   +1 more source

Prussia disaggregated : the demography of its universe of localities in 1871 [PDF]

open access: yes, 2020
We provide, for the first time, a detailed and comprehensive overview of the demography of more than 50,000 towns, villages, and manors in 1871 Prussia.
Becker, Sascha O., Cinnirella, Francesco
core   +3 more sources

The theory of war by Enrico Barone

open access: yesOpen Journal of Humanities, 2020
Barone proposes a theory of war influenced by marginalist theory and Prussian military thought which is critical of historical determinism and includes the belief that the main reason of social evolution is the search for power.
Catia Eliana Gentilucci
doaj   +1 more source

Oligonucleotide-Mediated, PCR-Independent Cloning by Homologous Recombination

open access: yesBioTechniques, 2001
We have developed an oligonucleotide-mediated cloning technique based on homologous recombination in Saccharomyces cerevisiae that allows precise DNA sequences to be transferred independent of restriction enzymes and PCR.
D.J. DeMarini   +6 more
doaj   +1 more source

TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis

open access: yesBlood Advances, 2017
: Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections.
Nicholas J. Laping   +10 more
doaj   +1 more source

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