Results 21 to 30 of about 29,696 (269)

A systems pharmacology model for gene therapy in sickle cell disease

CPT: Pharmacometrics & Systems Pharmacology, 2021
We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene.
Bo Zheng, Lucia Wille, Karsten Peppel, David Hagen, Andrew Matteson, Jeffrey Ahlers, James Schaff, Fei Hua, Theresa Yuraszeck, Enoch Cobbina, Joshua F. Apgar, John M. Burke, John Roberts, Raibatak Das   +13 more
doaj   +1 more source

Institutional Transplant and Cultural Proximity: Evidence from Nineteenth-Century Prussia

Journal Economic History, 2019
This article presents evidence that cultural proximity between the exporting and the receiving countries positively affects the adoption of new institutions and the resulting long-term economic outcomes. We obtain this result by combining new information
Giampaolo Lecce, L. Ogliari
semanticscholar   +1 more source

Performance Analysis of Different Types of Sensor Networks for Cognitive Radios

Journal of Electrical and Computer Engineering, 2012
We consider the problem of using multiple sensors to detect whether a certain spectrum is occupied or not. Each sensor sends its spectrum sensing result to a data fusion center, which combines all the results for an overall decision.
Chunxuan Ye, Zinan Lin, Alpaslan Demir, Yan Li   +3 more
doaj   +1 more source

Effect of CSL112 (apolipoprotein A‐I [human]) on cholesterol efflux capacity in Japanese subjects: Findings from a phase I study and a cross‐study comparison

Clinical and Translational Science, 2022
CSL112 (apolipoprotein A‐I [apoA‐I, human]) is a novel drug in development to reduce the risk of recurrent cardiovascular events following acute myocardial infarction by increasing cholesterol efflux capacity (CEC).
Bo Zheng, Shinya Goto, Regina Clementi, John Feaster, Danielle Duffy, Penelope Dalitz, Jolanta Airey, Serge Korjian, Michael A. Tortorici, John Roberts, C. Michael Gibson   +10 more
doaj   +1 more source

Wpływ zmian ustrojowych w Niemczech po I wojnie światowej na skład osobowy sejmów prowincjonalnych na Śląsku

Opolskie Studia Administracyjno-Prawne, 2020
The author presents the rules of suffrage that were binding in Zweites Reich (The Second Reich), that is the German Empire, during elections to provincial self-government in Prussia and then compares them with the new election law implemented in the ...
Tomasz Kruszewski
doaj   +1 more source

Historical Prussia in the mirror of confessional relations [PDF]

Слово.ру: балтийский акцент, 2014
This article develops the concept of historical process being determnined by cultural phenomena. The cultural aspect examined by the author is religious beliefs.
Shakhov V.
doaj  

Recombinant single‐chain factor VIII in severe hemophilia: Long‐term safety and efficacy in previously treated patients in the AFFINITY extension study

Research and Practice in Thrombosis and Haemostasis, 2022
Background rVIII‐SingleChain is a recombinant single‐chain factor VIII used to treat people with hemophilia A. Objectives The aim of this extension study was to investigate the long‐term safety and efficacy of rVIII‐SingleChain prophylaxis in ≥200 ...
Johnny Mahlangu, Faraizah Abdul Karim, Oleksandra Stasyshyn, Bartosz Korczowski, Blanca Salazar, Samantha Lucas, Amy Suen, Brahm Goldstein, Thomas Chung, Ingrid Pabinger   +9 more
doaj   +1 more source

Synthetic LXR agonists increase LDL in CETP species

Journal of Lipid Research, 2005
Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux, and possess both anti-inflammatory and antidiabetic actions ...
Pieter H.E. Groot, Nigel J. Pearce, John W. Yates, Claire Stocker, Charles Sauermelch, Christopher P. Doe, Robert N. Willette, Alan Olzinski, Tambra Peters, Denise d'Epagnier, Kathleen O. Morasco, John A. Krawiec, Christine L. Webb, Karpagam Aravindhan, Beat Jucker, Mark Burgert, Chun Ma, Joseph P. Marino, Jon L. Collins, Colin H. Macphee, Scott K. Thompson, Michael Jaye   +21 more
doaj   +1 more source

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2.
Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette   +31 more
doaj   +1 more source

A crítica da política e do Estado de Marx a partir das Glosas críticas ao artigo "O rei da Prússia e a reforma social. De um Prussiano"

Revista Marx e o Marxismo – Revista do NIEP-Marx, 2018
A contribuição teórica de Marx é marcada por dois momentos. Primeiramente, o autor dedica-se à crítica da filosofia alemã. Isso ocorre entre 1843-1846, e concretiza-se com A ideologia alemã.
José Luiz Alcantara
semanticscholar   +1 more source