Results 11 to 20 of about 80,471 (219)
Managing Drug-Drug Interactions Involving the Non-Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and intestinal efflux by P‐glycoprotein (P‐gp).
Zhou Z +6 more
europepmc +2 more sources
High-Sensitivity Hybridization Assay for Quantitation of Residual E. coli DNA
BioTechniques, 2002 Impurity assays for recombinant protein therapeutics are essential to ensure batchto-batch consistency and to meet the FDA's criteria for a well-characterized biopharmaceutical.
Xiaoying Ji, Kwan Lee, Byron DiPaolo
doaj +1 more source
A systems pharmacology model for gene therapy in sickle cell disease
CPT: Pharmacometrics & Systems Pharmacology, 2021 We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene.
Bo Zheng +13 more
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Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2023 Bu çalışma, 1834 yılında Prusya Krallığı’nın öncülüğünde kurulup 1919 yılına kadar varlığını sürdüren Zollverein ile Alman ulusal birliğinin kuruluşunun ilişkisini analiz etmektedir.
İbrahim Halil Menek
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Religious Tensions in Early Modern Torun, a History of War and Peace? [PDF]
, 2014 The history of acute inter-confessional conflict in Poland began with Martin Luther in 1517 and the presentation of the declaration of faith by the Protestants at the Diet of Augsburg in 1530.
Górska, Liliana
core +1 more source
The political economy of the Prussian three-class franchise [PDF]
, 2019 How did the Prussian three-class franchise, which politically over-represented the economic elite, affect policies? Contrary to the predominant and simplistic view that the system allowed the landed elites to capture most political rents, we find that ...
Becker, Sascha O., Hornung, Erik
core +2 more sources
Performance Analysis of Different Types of Sensor Networks for Cognitive Radios
Journal of Electrical and Computer Engineering, 2012 We consider the problem of using multiple sensors to detect whether a certain spectrum is occupied or not. Each sensor sends its spectrum sensing result to a data fusion center, which combines all the results for an overall decision.
Chunxuan Ye +3 more
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Synthetic LXR agonists increase LDL in CETP species
Journal of Lipid Research, 2005 Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux, and possess both anti-inflammatory and antidiabetic actions ...
Pieter H.E. Groot +21 more
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Clinical and Translational Science, 2022 CSL112 (apolipoprotein A‐I [apoA‐I, human]) is a novel drug in development to reduce the risk of recurrent cardiovascular events following acute myocardial infarction by increasing cholesterol efflux capacity (CEC).
Bo Zheng +10 more
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Opolskie Studia Administracyjno-Prawne, 2020 The author presents the rules of suffrage that were binding in Zweites Reich (The Second Reich), that is the German Empire, during elections to provincial self-government in Prussia and then compares them with the new election law implemented in the ...
Tomasz Kruszewski
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