Results 51 to 60 of about 15,848 (137)

Mitochondrial trafficking and distribution in primary embryonic neurons from APP, PS1 and APP/PS1 mice.

, 2012
A–C. Real time imaging of mitochondrial movement within the axon of Hip neuron from PS1 mouse 7 days in culture. A. Phase image of the axon; cell body is in the upper right corner. B. Same axon with mitochondria visualized using TMRM. Scale bar, 10 µm. C
Eugenia Trushina (180467), Ammar Siddiqui (180493), Jon Camp (180484), Yasushi Tamura (180498), Emirhan Nemutlu (180473), Janny Mesa (180488), Thomas M. Wengenack (180506), Petras P. Dzeja (180509), Song Zhang (180477), Trace Christensen (180480), Hiromi Sesaki (180502), Joseph F. Poduslo (180512)   +11 more
core   +1 more source

Review of "How had it ever happened here?": A Constructivist Reading of Thomas Pynchon's The Crying of Lot 49 and its Role in the Pynchon Canon, by Yvonne Klose (2012)

Orbit, 2012
Review of "How had it ever happened here?": A Constructivist Reading of Thomas Pynchon's The Crying of Lot 49 and its Role in the Pynchon Canon, by Yvonne Klose (2012)
Zac Rowlinson
doaj   +2 more sources

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

, 1998
We have examined the trafficking and metabolism of the β-amyloid precursor protein (APP), an APP homolog (APLP1), and TrkB in neurons that lack PS1. We report that PS1-deficient neurons fail to secrete Aβ, and that the rate of appearance of soluble APP ...
Ginty, David D, Price, Donald L, Borchelt, David R, Wong, Philip C, Naruse, Satoshi, Kusiak, John W, Iwatsubo, Takeshi, Qian, Xiaozhong, Sisodia, Sangram S, Luo, Jin-Jun, Thinakaran, Gopal, Tomita, Taisuke   +11 more
core   +1 more source

Pynchon's Public Profile (or lack thereof) – A Personal View

Orbit: Writing Around Pynchon, 2012
Letter about Thomas Pynchon's profile and 'Pynchon In Public Day' event.
John Dee
doaj   +1 more source

Thomas Pynchon and the Vacuum Salesman in Guadalajara

Orbit, 2013
The article documents the contents of Thomas Pynchon's essay "Hallowe'en? Over Already?," positing that the approach Pynchon takes to discussing the Cathedral of Saint John the Divine, a tour of which Pynchon describes provides an approach for writing a ...
Albert Rolls
doaj   +2 more sources

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice

, 2006
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Czech, Christian, Schindowski, Katharina, Eckert, Anne, Leutner, Silke, Luckhaus, Christian, Touchet, Nathalie, Müller, Walter E.   +6 more
core   +1 more source

Altered Expression of ZnT10 in Alzheimer's Disease Brain [PDF]

, 2013
There is an increasing body of evidence suggesting that metal homeostasis is dysregulated in the pathology of Alzheimer's disease (AD). Although expression levels of several transporters belonging the SLC30 family, which comprises predominantly zinc ...
Ruth A. Valentine (208371), Paul A Adlard, Ruth A. Valentine, Helen J. Bosomworth (417547), Ford, D, Bosomworth, Helen, Adlard, Paul, Dianne Ford, Valentine, Ruth, Paul A. Adlard, Paul A. Adlard (31148), Dianne Ford (174115), Bosomworth, HJ, Helen J Bosomworth, Ruth A Valentine, Skoulakis, Efthimios, Helen J. Bosomworth, Adlard, PA, Valentine, RA, Ford, Dianne   +19 more
core   +1 more source

Review of American Postmodernist Fiction and the Past, by Theophilus Savvas (2011)

Orbit: Writing Around Pynchon, 2012
Review of American Postmodernist Fiction and the Past, by Theophilus Savvas (2011)
David Letzler
doaj   +1 more source

Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer's Disease: a Review of Mechanism of Activation, Regulation, and Inhibition. [PDF]

Inflammation, 2023
Sharma B, Satija G, Madan A, Garg M, Alam MM, Shaquiquzzaman M, Khanna S, Tiwari P, Parvez S, Iqubal A, Haque SE, Khan MA.   +11 more
europepmc   +1 more source

Istradefylline, but not CGS 21680 HCl, attenuates the interaction between A_2AR and PS1 and influences the internal conformation of PS1.

, 2016
(A, B) HEK293 cells co-transfected with CFP-PS1 and A2AR-YFP were treated with Istradefylline (30 nM) for 0–60 min followed by the determination of FRET efficiency using acceptor photobleaching FRET (A) or FRET SE technique (B).
Jin Cui (638547), Yue Zhou (71752), Jian Zhao (219525), Xiaohang Li (555055), Ming Chen (115604), Xin Wang (91924), Jing Lu (120666), Gang Pei (274794), Wenjuan Yang (174250)   +8 more
core   +1 more source