Results 121 to 130 of about 1,006,016 (305)

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

open access: yesAdvanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet   +5 more
wiley   +1 more source

February Oversight Report

open access: yes, 2011
February report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the restriction and implementation of the U.S. Treasury's Troubled Asset Relief Program(TARP)
United States. Congressional Oversight Panel.
core  

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

open access: yesAdvanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu   +7 more
wiley   +1 more source

The Use of Pseudo Panel Data for Forecasting Car Ownership

open access: yes
While car ownership forecasting has always been a lively area of research, traditionally it was dominated by static models. To utilize the rich and readily available repeated cross sectional data sources and avoid the need for scarce and expensive panel ...
Huang, Biao
core  

January Oversight Report

open access: yes, 2010
January report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the winding down of the Troubled Asset Relief Program (TARP) and its impact on financial ...
United States. Congressional Oversight Panel.
core  

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

open access: yesAdvanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou   +12 more
wiley   +1 more source

Rationally Addicted to Cigarettes, Alcohol and Coffee? A Pseudo Panel Approach

open access: yes
In this paper, using pseudo panel data we analyze the relation between cigarette, alcohol, and coffee consumption within the rational addiction framework. Our purpose in this study is twofold.
Wohlgenant, Michael K., Koksal, Aycan
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

March Oversight Report

open access: yes, 2011
March final report of the U.S. Congressional Oversight Panel summarizing the events of the 2007-2008 financial crisis and providing an overview of the impacts on various economic sectors, governmental financial assistance programs, and lessons ...
United States. Congressional Oversight Panel.
core  

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

open access: yesAdvanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao   +7 more
wiley   +1 more source

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