Results 101 to 110 of about 14,400 (274)
, 2016 We develop a stochastic model for the programmed frameshift of ribosomes synthesizing a protein while moving along a mRNA template. Normally the reading frame of a ribosome decodes successive triplets of nucleotides on the mRNA in a step-by-step manner ...
Chowdhury, Debashish +2 more
core +1 more source
ChemBioChem, Volume 26, Issue 10, May 27, 2025.Rational design is a potent strategy for developing ribozymes with advanced functionalities. Engineered variants of the hairpin ribozyme impressively demonstrate how function can be tuned through structural manipulation. The engineering of nucleic acids has been a longstanding objective in research, with the field gaining significant attention ...
Constanze Ebermann, Sabine Müller
wiley +1 more source
Theoretical Search for RNA Folding Nuclei
Entropy, 2015 The functions of RNA molecules are defined by their spatial structure, whose folding is regulated by numerous factors making RNA very similar to proteins.
Leonid B. Pereyaslavets +1 more
doaj +1 more source
Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA
, 2011 Formation of a pseudoknot in the conserved RNA core domain in the ribonucleoprotein human telomerase is required for function. In vitro experiments show that the pseudoknot (PK) is in equilibrium with an extended hairpin (HP) structure.
Antal M. +30 more
core +1 more source
Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate.
Journal of the American Chemical Society, 2017 The twister RNA is a recently discovered nucleolytic ribozyme that is present in both bacteria and eukarya. While its biological role remains unclear, crystal structure analyses and biochemical approaches have revealed critical features of its catalytic ...
Nikola Vušurović +4 more
semanticscholar +1 more source
Advanced Materials Technologies, Volume 10, Issue 9, May 6, 2025.Non‐faradaic label‐free impedimetric determination of cortisol is demonstrated with gold nanoparticles (AuNP) functionalized laser‐induced graphene interdigitated electrodes (LIG‐IDE). The AuNP functionalized LIG‐IDE exhibits remarkable characteristics including good logarithmic linear range, high reproducibility, repeatability, and robust selectivity.
Kyle Duke +9 more
wiley +1 more source
Combinatorial design of pseudoknot RNA
Advances in Applied Mathematics, 2009 AbstractIn this paper we enumerate k-noncrossing RNA pseudoknot structures with given minimum stack-length, σ. One main result of the paper is the asymptotic formula for their number: Tk,σ(n)∼n−((k−1)2+(k−1)/2)γk,σ−n, where γk,σ is explicitly known.
Emma Yu Jin, Christian M. Reidys
openaire +2 more sources
Aptamer and DNAzyme Based Colorimetric Biosensors for Pathogen Detection
Angewandte Chemie, Volume 137, Issue 4, January 21, 2025.Pathogen detection is crucial for preventing and managing health risks. This review consolidates the selection of functional nucleic acids (FNAs) for pathogen detection and the development of cost‐effective, simple diagnostic applications. It focuses on integrating FNAs with gold nanoparticles, polydiacetylenes, protein enzymes, G‐quadruplexes, and ...
Rudi Liu +3 more
wiley +2 more sources
eLife, 2015 Internal ribosome entry sites (IRESs) are powerful model systems to understand how the translation machinery can be manipulated by structured RNAs and for exploring inherent features of ribosome function.
Marisa D Ruehle +7 more
doaj +1 more source
Insights into factorless translational initiation by the tRNA-like pseudoknot domain of a viral IRES. [PDF]
PLoS ONE, 2012 The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae family adopts an overlapping triple pseudoknot structure to directly recruit the 80S ribosome in the absence of initiation factors.
Hilda H T Au, Eric Jan
doaj +1 more source