Results 131 to 140 of about 14,834 (261)

Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot

open access: yesPLoS ONE, 2016
The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent viral translation is a primary target for small interfering RNA (siRNA)-based HCV antiviral therapy. However, identification of potent siRNAs against HCV IRES by
Jae-Su Moon   +9 more
semanticscholar   +1 more source

Targeting G‐Rich lncRNA and Its Structural Polymorphism With Selective G‐Quadruplex Ligands: An NMR Study

open access: yesChemistry – A European Journal, Volume 31, Issue 72, December 23, 2025.
The REG1CP‐derived RNA oligonucleotide SL15P adopts a parallel G‐quadruplex (rGQ) structure. In this study, we investigate the effect of several well‐characterized ligands, originally developed for DNA GQs, on the RNA counterpart, with the aim of evaluating their binding ability and specific binding modes.
Giuseppe Satta   +2 more
wiley   +1 more source

Classifying RNA pseudoknotted structures

open access: yesTheoretical Computer Science, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Condon, Anne   +4 more
openaire   +4 more sources

Ensemble simulations: folding, unfolding and misfolding of a high-efficiency frameshifting RNA pseudoknot

open access: yesNucleic Acids Research, 2017
Massive all-atom molecular dynamics simulations were conducted across a distributed computing network to study the folding, unfolding, misfolding and conformational plasticity of the high-efficiency frameshifting double mutant of the 26 nt potato leaf ...
Khai K. Q. Nguyen   +7 more
semanticscholar   +1 more source

Integrative In Silico and In Vitro Screening of Low Molecular Weight Compounds Targeting SARS‐CoV‐2 RNA Elements

open access: yesChemBioChem, Volume 26, Issue 24, December 11, 2025.
A combined virtual and nuclear magnetic resonance (NMR)‐based screening approach identifies small molecules that bind conserved SARS‐CoV‐2 RNA structures. Diverse compound libraries are screened using full‐atom refinement 2‐generated ensembles of stem‐loop 1 and the frameshift pseudoknot. Predicted hits are validated by ligand‐ and target‐detected NMR,
Sabrina Toews   +4 more
wiley   +1 more source

Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for −1 ribosomal frameshifting stimulation

open access: yesScientific Reports, 2016
Minus-one ribosomal frameshifting is a translational recoding mechanism widely utilized by many RNA viruses to generate accurate ratios of structural and catalytic proteins. An RNA pseudoknot structure located in the overlapping region of the gag and pro
Zhensheng Zhong   +8 more
semanticscholar   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

open access: yesAdvanced Engineering Materials, Volume 27, Issue 22, November 2025.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems

open access: yesAggregate, Volume 6, Issue 11, November 2025.
Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo   +6 more
wiley   +1 more source

Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle‐Based Delivery

open access: yesThe Chemical Record, Volume 25, Issue 10, October 2025.
This review explores aptamers as therapeutic oligonucleotides targeting neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's, with a focus on G‐quadruplex‐forming sequences. It discusses chemical modifications that enhance aptamer stability and function, alongside the use of clay nanoparticles, such as halloysite nanotubes ...
Valentina Arciuolo   +9 more
wiley   +1 more source

Pseudoknot Identification through Learning TAGRNA [PDF]

open access: yes, 2008
Studying the structure of RNA sequences is an important problem that helps in understanding the functional properties of RNA. Pseudoknot is one type of RNA structures that cannot be modeled with Context Free Grammars (CFG) because it exhibits crossing dependencies.
Seesi, Sahar Al   +2 more
openaire   +1 more source

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