Results 131 to 140 of about 14,834 (261)
PLoS ONE, 2016 The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent viral translation is a primary target for small interfering RNA (siRNA)-based HCV antiviral therapy. However, identification of potent siRNAs against HCV IRES by
Jae-Su Moon +9 more
semanticscholar +1 more source
Chemistry – A European Journal, Volume 31, Issue 72, December 23, 2025.The REG1CP‐derived RNA oligonucleotide SL15P adopts a parallel G‐quadruplex (rGQ) structure. In this study, we investigate the effect of several well‐characterized ligands, originally developed for DNA GQs, on the RNA counterpart, with the aim of evaluating their binding ability and specific binding modes.
Giuseppe Satta +2 more
wiley +1 more source
Classifying RNA pseudoknotted structures
Theoretical Computer Science, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Condon, Anne +4 more
openaire +4 more sources
Nucleic Acids Research, 2017 Massive all-atom molecular dynamics simulations were conducted across a distributed computing network to study the folding, unfolding, misfolding and conformational plasticity of the high-efficiency frameshifting double mutant of the 26 nt potato leaf ...
Khai K. Q. Nguyen +7 more
semanticscholar +1 more source
ChemBioChem, Volume 26, Issue 24, December 11, 2025.A combined virtual and nuclear magnetic resonance (NMR)‐based screening approach identifies small molecules that bind conserved SARS‐CoV‐2 RNA structures. Diverse compound libraries are screened using full‐atom refinement 2‐generated ensembles of stem‐loop 1 and the frameshift pseudoknot. Predicted hits are validated by ligand‐ and target‐detected NMR,
Sabrina Toews +4 more
wiley +1 more source
Scientific Reports, 2016 Minus-one ribosomal frameshifting is a translational recoding mechanism widely utilized by many RNA viruses to generate accurate ratios of structural and catalytic proteins. An RNA pseudoknot structure located in the overlapping region of the gag and pro
Zhensheng Zhong +8 more
semanticscholar +1 more source
Advanced Engineering Materials, Volume 27, Issue 22, November 2025.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems
Aggregate, Volume 6, Issue 11, November 2025.Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo +6 more
wiley +1 more source
The Chemical Record, Volume 25, Issue 10, October 2025.This review explores aptamers as therapeutic oligonucleotides targeting neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's, with a focus on G‐quadruplex‐forming sequences. It discusses chemical modifications that enhance aptamer stability and function, alongside the use of clay nanoparticles, such as halloysite nanotubes ...
Valentina Arciuolo +9 more
wiley +1 more source
Pseudoknot Identification through Learning TAGRNA [PDF]
, 2008 Studying the structure of RNA sequences is an important problem that helps in understanding the functional properties of RNA. Pseudoknot is one type of RNA structures that cannot be modeled with Context Free Grammars (CFG) because it exhibits crossing dependencies.
Seesi, Sahar Al +2 more
openaire +1 more source