Results 11 to 20 of about 14,834 (261)
Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers. [PDF]
PLoS Computational Biology, 2021 The coronavirus causing the COVID-19 pandemic, SARS-CoV-2, uses -1 programmed ribosomal frameshifting (-1 PRF) to control the relative expression of viral proteins. As modulating -1 PRF can inhibit viral replication, the RNA pseudoknot stimulating -1 PRF
Sara Ibrahim Omar +5 more
doaj +3 more sources
Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles [PDF]
Nature Communications, 2021 Development of Cas12a for human therapeutics and diagnostics may significantly benefit from, or even require, chemical modification of its guide RNA. Here the authors show that the noncanonical 5′ pseudoknot structure of the AsCas12a crRNA guide can be ...
Eman A. Ageely +7 more
doaj +3 more sources
A steepest descent calculation of RNA pseudoknots [PDF]
Physical Review E, 2002 We enumerate possible topologies of pseudoknots in single-stranded RNA molecules. We use a steepest-descent approximation in the large N matrix field theory, and a Feynman diagram formalism to describe the resulting pseudoknot ...
A. Zee +3 more
core +7 more sources
Possible involvement of three-stemmed pseudoknots in regulating translational initiation in human mRNAs. [PDF]
PLoS ONERNA pseudoknots play a crucial role in various cellular functions. Established pseudoknots show significant variation in both size and structural complexity. Specifically, three-stemmed pseudoknots are characterized by an additional stem-loop embedded in
Xiaolan Huang, Zhihua Du
doaj +4 more sources
Nature Communications, 2021 The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with ...
Krishna Neupane +8 more
doaj +2 more sources
Scientific Reports, 2022 Pepino mosaic virus (PepMV) is a potexvirus of the family Alphaflexiviridae within the order of Tymovirales that threatens tomato production worldwide.
René C. L. Olsthoorn +2 more
doaj +2 more sources
Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA [PDF]
, 2011 Formation of a pseudoknot in the conserved RNA core domain in the ribonucleoprotein human telomerase is required for function. In vitro experiments show that the pseudoknot (PK) is in equilibrium with an extended hairpin (HP) structure.
Antal M. +30 more
core +2 more sources
Methods and Protocols, 2022 Obtaining valuable clues for noncoding RNA (ribonucleic acid) subsequences remains a significant challenge, acknowledging that most of the human genome transcribes into noncoding RNA parts related to unknown biological operations.
Christos Andrikos +5 more
doaj +2 more sources
Salt-Dependent RNA Pseudoknot Stability: Effect of Spatial Confinement
Frontiers in Molecular Biosciences, 2021 Macromolecules, such as RNAs, reside in crowded cell environments, which could strongly affect the folded structures and stability of RNAs. The emergence of RNA-driven phase separation in biology further stresses the potential functional roles of ...
Chenjie Feng +4 more
doaj +2 more sources
Shapify: Paths to SARS-CoV-2 frameshifting pseudoknot.
PLoS Computational Biology, 2023 Multiple coronaviruses including MERS-CoV causing Middle East Respiratory Syndrome, SARS-CoV causing SARS, and SARS-CoV-2 causing COVID-19, use a mechanism known as -1 programmed ribosomal frameshifting (-1 PRF) to replicate.
Luke Trinity +4 more
doaj +2 more sources