Results 31 to 40 of about 14,400 (274)

Atomistic structure of the SARS-CoV-2 pseudoknot in solution from SAXS-driven molecular dynamics. [PDF]

Nucleic Acids Res, 2023
SARS-CoV-2 depends on −1 programmed ribosomal frameshifting (−1 PRF) to express proteins essential for its replication. The RNA pseudoknot stimulating −1 PRF is thus an attractive drug target.
He W, San Emeterio J, Woodside MT, Kirmizialtin S, Pollack L.   +4 more
europepmc   +2 more sources

Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression

Nature Communications, 2022
The SARS-CoV-2 frameshifting element (FSE), a highly conserved mRNA region required for correct translation of viral polyproteins, defines an excellent therapeutic target against Covid-19.
Shuting Yan, Qiyao Zhu, Swati Jain, T. Schlick   +3 more
semanticscholar   +1 more source

Conformational entropy of a pseudoknot polymer [PDF]

The Journal of Chemical Physics, 2006
The thermodynamics and kinetics of ABAB pseudoknot formation owing to reversible intrachain reactions are investigated for a flexible polymer based on the off-lattice Monte Carlo simulations. The polymer is made of N hard spheres tethered by inextensible bonds and consists of two reactive pairs AA and BB with binding energies −ε1 and −ε2, respectively,
Yu‐Jane Sheng, You-Chin Mou, Heng‐Kwong Tsao   +2 more
openalex   +4 more sources

Role of an RNA pseudoknot involving the polyA tail in replication of Pepino mosaic potexvirus and related plant viruses

Scientific Reports, 2022
Pepino mosaic virus (PepMV) is a potexvirus of the family Alphaflexiviridae within the order of Tymovirales that threatens tomato production worldwide.
René C. L. Olsthoorn, Carolyn A. Owen, Ioannis C. Livieratos   +2 more
doaj   +1 more source

Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot

RNA: A publication of the RNA Society, 2021
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed −1 ribosomal frameshifting.
Christopher P Jones, A. Ferré-D’Amaré   +1 more
semanticscholar   +1 more source

RbfA Is Involved in Two Important Stages of 30S Subunit Assembly: Formation of the Central Pseudoknot and Docking of Helix 44 to the Decoding Center

International Journal of Molecular Sciences, 2021
Ribosome biogenesis is a highly coordinated and complex process that requires numerous assembly factors that ensure prompt and flawless maturation of ribosomal subunits.
E. Maksimova, A. Korepanov, O. Kravchenko, T. Baymukhametov, A. Myasnikov, K. Vassilenko, Z. Afonina, E. Stolboushkina   +7 more
semanticscholar   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Insights into the secondary and tertiary structure of the Bovine Viral Diarrhea Virus Internal Ribosome Entry Site

RNA Biology, 2022
The internal ribosome entry site (IRES) RNA of bovine viral diarrhoea virus (BVDV), an economically significant Pestivirus, is required for the cap-independent translation of viral genomic RNA. Thus, it is essential for viral replication and pathogenesis.
Devadatta Gosavi, Iwona Wower, Irene K. Beckmann, Ivo L. Hofacker, Jacek Wower, Michael T. Wolfinger, Joanna Sztuba-Solinska   +6 more
doaj   +1 more source

Disentangling the pseudoknots of toxin translation. [PDF]

Proc Natl Acad Sci U S A
Jagodnik J, Darfeuille F, Guillier M.
europepmc   +3 more sources

Chelated Magnesium Logic Gate Regulates Riboswitch Pseudoknot Formation.

Journal of Physical Chemistry B, 2021
Magnesium plays a critical role in the structure, dynamics, and function of RNA. The precise microscopic effect of chelated magnesium on RNA structure is yet to be explored.
Raju Sarkar, Akhilesh Jaiswar, S. Hennelly, J. Onuchic, K. Sanbonmatsu, Susmita Roy   +5 more
semanticscholar   +1 more source