Results 31 to 40 of about 14,834 (261)

RNA pseudoknots

Current Opinion in Structural Biology, 1992
RNA pseudoknots result from Watson-Crick base pairing involving a stretch of bases located between paired strands and a distal single-stranded region. Recently, significant advances in our understanding of their structural and functional aspects have been accomplished.
Éric Westhof, Luc Jaeger
openalex   +3 more sources

Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension [PDF]

Journal of Molecular Biology, 2016
Because of the potential link between -1 programmed ribosomal frameshifting and response of a pseudoknot (PK) RNA to force, a number of single molecule pulling experiments have been performed on PKs to decipher the mechanism of programmed ribosomal ...
Denesyuk, Natalia A., Hori, Naoto, Thirumalai, D.   +2 more
core   +2 more sources

Optimization of Structure‐Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2 [PDF]

Angewandte Chemie
Targeting the RNA genome of SARS-CoV-2 is a viable option for antiviral drug development. We explored three ligand binding sites of the core pseudoknot RNA of the SARS-CoV-2 frameshift element.
Harald Schwalbe, Betül Ceylan, Jennifer Adam, Sabrina Toews, Frank J. Kaiser, Jonas Doerr, Daniel Scheppa, Jan‐Niklas Tants, Alexandria Smart, Julian Schoth, Stephan Philipp, Elke Stirnal, Jan Ferner, Christian Richter, Sridhar Sreeramulu, Neva Caliskan, Andreas Schlundt, Julia E. Weigand, Michael Göbel, Anna Wacker   +19 more
openalex   +2 more sources

Identification of the RNA Pseudoknot within the 3′ End of the Porcine Reproductive and Respiratory Syndrome Virus Genome as a Pathogen-Associated Molecular Pattern To Activate Antiviral Signaling via RIG-I and Toll-Like Receptor 3 [PDF]

Journal of Virology, 2018
Once infected by viruses, cells can detect pathogen-associated molecular patterns (PAMPs) on viral nucleic acid by host pattern recognition receptors (PRRs) to initiate the antiviral response.
Sha Xie, Xinxin Chen, Songlin Qiao, Rui Li, Yan-Gang Sun, Shuangfei Xia, Lin-Jian Wang, Xuegang Luo, Ruiguang Deng, En‐Min Zhou, Gaiping Zhang   +10 more
openalex   +2 more sources

Atomistic structure of the SARS-CoV-2 pseudoknot in solution from SAXS-driven molecular dynamics

Nucleic Acids Research, 2023
SARS-CoV-2 depends on −1 programmed ribosomal frameshifting (−1 PRF) to express proteins essential for its replication. The RNA pseudoknot stimulating −1 PRF is thus an attractive drug target.
Weiwei He, Josue San Emeterio, M. Woodside, Serdal Kirmizialtin, Lois Pollack   +4 more
semanticscholar   +1 more source

Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression

Nature Communications, 2022
The SARS-CoV-2 frameshifting element (FSE), a highly conserved mRNA region required for correct translation of viral polyproteins, defines an excellent therapeutic target against Covid-19.
Shuting Yan, Qiyao Zhu, Swati Jain, T. Schlick   +3 more
semanticscholar   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot

RNA: A publication of the RNA Society, 2021
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed −1 ribosomal frameshifting.
Christopher P Jones, A. Ferré-D’Amaré   +1 more
semanticscholar   +1 more source

RbfA Is Involved in Two Important Stages of 30S Subunit Assembly: Formation of the Central Pseudoknot and Docking of Helix 44 to the Decoding Center

International Journal of Molecular Sciences, 2021
Ribosome biogenesis is a highly coordinated and complex process that requires numerous assembly factors that ensure prompt and flawless maturation of ribosomal subunits.
E. Maksimova, A. Korepanov, O. Kravchenko, T. Baymukhametov, A. Myasnikov, K. Vassilenko, Z. Afonina, E. Stolboushkina   +7 more
semanticscholar   +1 more source

Insights into the secondary and tertiary structure of the Bovine Viral Diarrhea Virus Internal Ribosome Entry Site

RNA Biology, 2022
The internal ribosome entry site (IRES) RNA of bovine viral diarrhoea virus (BVDV), an economically significant Pestivirus, is required for the cap-independent translation of viral genomic RNA. Thus, it is essential for viral replication and pathogenesis.
Devadatta Gosavi, Iwona Wower, Irene K. Beckmann, Ivo L. Hofacker, Jacek Wower, Michael T. Wolfinger, Joanna Sztuba-Solinska   +6 more
doaj   +1 more source