Results 1 to 10 of about 87,297 (193)

Clostridioides difficile‐Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Clostridioides difficile (CD) is a leading cause of antibiotic‐associated diarrhoea in both hospitalized and non‐hospitalized patients. This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strain 630 (CD630‐EVs), which released spherical EVs during in vitro culture, in modulating pro‐inflammatory ...
Fangfang Fan, Yu Zeng, Qianli Zhao, Tongxuan Su, Yining Shen, Wei Chen, Cen Jiang, Qi Ni, Yiyue Liu, Ru Fan, Danfeng Dong, Yibing Peng   +11 more
wiley   +1 more source

Pseudomembranous colitis: fatal clostridium difficile infection in pregnancy

Asian Journal of Internal Medicine
Clostridium difficile infection (CDI) is a disease primarily affecting the large intestine, characterised by diarrhoea, abdominal pain and fever due to enterotoxins.
I. Jenosha, G. Selvaratnam, J. A. Pradeepan, T. Kumanan, S. Pranavan   +4 more
doaj   +1 more source

Ionomycin Exhibits Potent and Selective Bactericidal Activity Against Clostridioides difficile Through Calcium‐Dependent Membrane Disruption

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Ionomycin exhibits potent and selective bactericidal activity against Clostridioides difficile, rapidly reducing vegetative cells, toxin production, sporulation, and spore germination while sparing representative gut microbiota. Its activity is calcium‐dependent and mediated through disruption of bacterial membrane potential, highlighting ionomycin as ...
Ahmed A. Abouelkhair, Nader S. Abutaleb, Mohamed N. Seleem   +2 more
wiley   +1 more source

Fecal Transplantation for —“All Stool May Not Be Created Equal”

Journal of the International Association of Providers of AIDS Care, 2016
Clostridium difficile is a gram-positive bacterium that is recognized as a causative organism of pseudomembranous enterocolitis. This infection has become a major public health challenge and is a source of considerable morbidity and mortality in those ...
Joseph C. Gathe MD, FACP, FIDSA, Efemena M. Diejomaoh MBBS, Carl C. Mayberry PA, John B. Clemmons MD   +3 more
doaj   +1 more source

Sequential use of Antibiotics and Adjuvant Chemotherapy Leading to a Fatal Pseudomembranous Colitis

McGill Journal of Medicine, 2020
N ...
Mark Basik, Barbara Roback, Marc Trudeau
doaj   +1 more source

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

Microbiology and Immunology, Volume 70, Issue 4, Page 206-213, April 2026.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa, Tatsuki Miyamoto, Rino Isshiki, Tomoyoshi Kaneko, Kenichi Takasugi, Naohiro Noda, Satoshi Tsuneda   +6 more
wiley   +1 more source

Pseudomembranous colitis and toxic megacolon due to C. difficile in an inpatient hospitalized for home accident

Clinical Management Issues, 2015
Clostridium difficile infection (CDI) is the main cause of hospital-acquired diarrhea. It can result in symptoms ranging from moderate diarrhea to pseudomembranous colitis.
Piergiorgio Chiriacò
doaj   +1 more source

Electroelution Into a Salt Trap: Reviving an Old‐School Approach to DNA Purification

Small Methods, Volume 10, Issue 5, 9 March 2026.
Electroelution into a salt cushion is a well‐established yet underutilized method of capturing gel‐purified nucleic acids. This Perspective discusses how this traditional method can be reengineered to meet the demands of next‐generation technologies, such as long‐read sequencing.
Ruslan Kalendar, Konstantin I. Ivanov, Olga V. Samuilova, Timo Burster, Andrey A. Zamyatnin Jr.   +4 more
wiley   +1 more source

Comprehensive Evaluation of the Efficacy and Safety of the Clostridioides difficile Toxoid Vaccine: A Meta‐Analysis

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Clostridioides difficile infection (CDI) significantly contributes to healthcare‐associated morbidity and mortality. Vaccination against C. difficile toxins may provide an effective preventive strategy, yet current data remain inconclusive. This meta‐analysis evaluates the efficacy, immunogenicity, and safety of the C.
Muhammad Shahzil, Zainab Jamil, Saleha Azeem, Minahel Shehzadi, Aisha Shabbir, Muhammad Saad Faisal, Fariha Hasan, Muhammad Ali Khaqan, Ammad Javaid Chaudhary, Syed-Mohammed Jafri, Satabdi Datta Choudhury   +10 more
wiley   +1 more source

Pneumatosis Coli Associated with Pseudomembranous Colitis in a Patient following Colonic Surgery

Case Reports in Medicine, 2010
Pneumatosis intestinalis is a rare disorder characterized by gas-filled cysts within the subserosal and/or submucosal regions of the intestinal wall. The source of this gas and its translocation across the mucosa is incompletely understood.
Jennifer Bailey, Eldon A. Shaffer
doaj   +1 more source