Results 251 to 260 of about 863,963 (349)

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries

open access: yesiMetaOmics, EarlyView.
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo   +9 more
wiley   +1 more source

Resistome flow in global landfill systems

open access: yesiMetaOmics, EarlyView.
Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid‐driven gene mobility. Waste flows and environmental pathways sustain the transboundary resistome networks, accelerating resistance dissemination across ecosystems.
Wenqing Hong   +12 more
wiley   +1 more source

Broad‐Spectrum Antimicrobial and Biofilm‐Disrupting Activity of D7: A Novel Disinfectant Effective Against Pseudomonas aeruginosa and Other Clinically Relevant Pathogens

open access: yesiNew Medicine, EarlyView.
ABSTRACT Biofilm‐associated contamination and the presence of multiple pathogenic species on environmental and medical surfaces pose a major challenge in healthcare and hygiene management, contributing significantly to hospital‐acquired infections (HAIs).
Shanghui Gao   +6 more
wiley   +1 more source

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

open access: yesInterdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan   +2 more
wiley   +1 more source

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