Results 201 to 210 of about 488,525 (347)

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

Interdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan, Adnan Shakoor, Sadia Kanwal   +2 more
wiley   +1 more source

Unleashing AdipoRon’s Potential: A Fresh Approach to Tackle Pseudomonas aeruginosa Infections in Bronchiectasis via Sphingosine Metabolism Modulation

Journal of Inflammation Research
Jia-wei Xu,1,2,* Fang-fang Chen,1,* Ying-hui Qv,1,* Cong-cong Sun,1 Dong Zhang,1,2 Zhi Guo,1 Yu-jiao Wang,3 Jun-fei Wang,4 Tian Liu,4 Liang Dong,1,2 Qian Qi1,2 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital
Xu JW, Chen FF, Qv YH, Sun CC, Zhang D, Guo Z, Wang YJ, Wang JF, Liu T, Dong L, Qi Q   +10 more
doaj  

Bile modulates phage-host interactions in multidrug-resistant Pseudomonas aeruginosa. [PDF]

BMC Microbiol
Khan MSI, Wu J, Hou S, Ji S, Li H, Chang Y, Sui B, Tan D, Yin J.   +8 more
europepmc   +1 more source

Genetic Evidence Implicating Gut Microbiota and Circulating Cytokines in Sjögren's Syndrome

Journal of Clinical Laboratory Analysis, EarlyView.
Complex bidirectional causal relationships were found between gut microbiota abundance and Sjögren's syndrome (SS). Five circulating cytokines were shown to potentially affect SS, including MIG, IL‐5, IL‐1RA, IL‐2RA, and SCGF‐β, and SS was found to increase levels of two circulating cytokines, IL‐1β and IL‐5.
Yuchen Cai, Tianyi Zhou, Wenjun Shi, Xia Ding, Xueyao Cai, Li Yu   +5 more
wiley   +1 more source

Mortality after broad‐ versus narrow‐spectrum antibiotic treatment for patients with nursing and healthcare‐associated pneumonia: A nationwide retrospective cohort study

Journal of Hospital Medicine, EarlyView.
Abstract Background Nursing and healthcare‐associated pneumonia (NHCAP) is defined as pneumonia occurring in individuals with frequent healthcare contact, such as residents of care facilities or patients with impaired activities of daily living. The effectiveness of broad‐spectrum antibiotics in treating NHCAP remains unclear.
Jumpei Taniguchi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga   +4 more
wiley   +1 more source

ECF Sigma Factor HxuI Is Critical for In Vivo Fitness of Pseudomonas aeruginosa during Infection

, 2022
Zeqiong Cai, Fan Yang, Xiaolong Shao, Zhuo Yue, Zhenpeng Li, Yuqin Song, Xiaolei Pan, Yongxin Jin, Zhihui Cheng, Un‐Hwan Ha, Jie Feng, Liang Yang, Xin Deng, Weihui Wu, Fang Bai   +14 more
openalex   +1 more source

The influence of <i>Pseudomonas aeruginosa</i> infection on the airway metabolome. [PDF]

Microbiology (Reading)
Green AE, Ruhluel D, Phelan M, Fothergill JL, Neill DR.   +4 more
europepmc   +1 more source

Bacteria produce and use redox mediators for electron transfer in microbial fuel cells [PDF]

, 2004
Boon, Nico, Denef, Vincent, Höfte, Monica, Rabaey, Korneel, Verhaege, Marc, Verstraete, Willy   +5 more
core  

Laser Disinfection Acts as Biofilm‐Disrupter in Periprosthetic Joint Infection (PJI)

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Infections after joint arthroplasties represent a devastating and progressively escalating complication with increased morbidity and mortality. The eradication of biofilms from infected implants is still an unsolved challenge. The erbium‐doped yttrium aluminum garnet (Er:YAG) laser, which delivers high‐energy light for rapid tissue ablation ...
Lukas K. Kriechbaumer, Christian Deininger, Alexander Planitzer, Marian Mitterer, Wolfgang Happak, Sylvia Nürnberger, Patrick Marko, Sebastian Filipp, Gerhild Thalhammer, Stephan Frenzel, Laura Hruby, Gundobert Korn   +11 more
wiley   +1 more source

Multiresistant Pseudomonas aeruginosa serogroup O:11 outbreak in an intensive care unit [PDF]

, 1997
Panayotis T. Tassios, Vassiliki Gennimata, Lemonia Spaliara-Kalogeropoulou, Chryssa Koutsia, Alkiviadis Vatopoulos, N.J. Legakis, Dimitris Kairis   +6 more
openalex   +1 more source