Results 201 to 210 of about 431,868 (287)

Structural analysis of the NifL‐NifA complex reveals the molecular basis of anti‐activation of nitrogen fixation gene expression in Azotobacter vinelandii

The FEBS Journal, EarlyView.
Using cryo‐EM combined with biochemical and genetic approaches, we mapped the interaction surface between NifL and NifA to gain insights into the regulation of nitrogen fixation genes in A. vinelandii. Our findings suggest that NifL, a homolog of histidine kinases lacking phosphorylation activity, evolved to act as a steric block of NifA activity ...
Marcelo Bueno Batista, Jake Richardson, Michael W. Webster, Dmitry Ghilarov, John W. Peters, David M. Lawson, Ray Dixon   +6 more
wiley   +1 more source

Heteromultivalent Nanogels as Highly Potent Inhibitors of Pseudomonas Aeruginosa. [PDF]

Angew Chem Int Ed Engl
Jiang Y, Nie C, Zheng B, Khatri V, Puccio D, Long Y, Dimde M, Haag R, Bhatia S.   +8 more
europepmc   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Physicochemical and Functional Characterizations of Biosurfactants Produced by Pseudomonas aeruginosa N33 for Oil Removal. [PDF]

Microorganisms
Zhao X, Jiang M, Du T, Liu X, Luo J, Guo Y, Li X, Wang H, Wei S, Yu L.   +9 more
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Pharmacodynamic individualization of phage therapy against a KPC-5-producing Pseudomonas aeruginosa. [PDF]

JAC Antimicrob Resist
Nguyen TD, Sanborn JT, Ho BM, Luong T, Wood TD, Chen L, Roach DR, Smith NM.   +7 more
europepmc   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Analyzing the effects of benzodiazepines on the virulence and biofilm formation of Pseudomonas aeruginosa. [PDF]

Sci Rep
Barceló IM, Jordana-Lluch E, Escobar-Salom M, Sansó-Sastre J, Coll-Matas MÀ, Estévez MÁ, González-Alsina À, Tomàs A, Tortosa M, Torrens G, Albertí S, Oliver A, Juan C.   +12 more
europepmc   +1 more source