Microorganisms, 2022 Pseudomonas aeruginosa is a dominant cause of respiratory infection in individuals with cystic fibrosis (CF), leading to significant morbidity and mortality. Detection of P.
Thang V. Truong +8 more
doaj +1 more source
BMC Research Notes, 2020 Pseudomonas aeruginosa is known as a leading cause of nosocomial infections worldwide. Antimicrobial resistance and biofilm production, as two main virulence factors of P. aeruginosa, are responsible for the persistence of prolonged infections.
E. Kamali +4 more
semanticscholar +1 more source
Quorum Sensing Inhibitory Activities of Oridonin in Pseudomonas Aeruginosa [PDF]
E3S Web of Conferences, 2021 Pseudomonas aeruginosa is an opportunistic pathogen, and it can produce cell-associated and extracellular virulence factors. Several of these virulence factors have been demonstrated to be regulated by quorum sensing (QS).
Huang Jing, Li Haoming
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The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa [PDF]
, 2006 Certain members of the fluorescent pseudomonads produce and secrete phenazines. These heterocyclic, redox-active compounds are toxic to competing organisms, and the cause of these antibiotic effects has been the focus of intense research efforts.
Dietrich, Lars E. P. +4 more
core +1 more source
Ferric uptake regulator Fur is conditionally essential in Pseudomonas aeruginosa [PDF]
, 2017 In Pseudomonas aeruginosa, the ferric uptake regulator (Fur) protein controls both metabolism and virulence in response to iron availability. Differently from other bacteria, attempts to obtain fur deletion mutants of P. aeruginosa failed, leading to the
Banin, Ehud +6 more
core +1 more source
Antimicrobial Resistance in Pseudomonas aeruginosa Biofilms
Journal of Pure and Applied Microbiology, 2021 Pseudomonas aeruginosa (PA) is part of a group of common nosocomial pathogens that exhibit multidrug resistance, thus proving to be a significant threat to healthcare.
Dhara Patel +5 more
doaj +1 more source
Early childhood lung function is a stronger predictor of adolescent lung function in cystic fibrosis than early Pseudomonas aeruginosa infection [PDF]
, 2017 Pseudomonas aeruginosa has been suggested as a major determinant of poor pulmonary outcomes in cystic fibrosis (CF), although other factors play a role.
Accurso, Frank J +9 more
core +4 more sources
Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum [PDF]
, 2017 In vitro models that mimic in vivo host-pathogen interactions are needed to evaluate candidate drugs that inhibit bacterial virulence traits. We established a new approach to study Pseudomonas aeruginosa biofilm susceptibility on biotic surfaces, using a
Coenye, Tom +11 more
core +1 more source
Effect of local stress on accurate modeling of bacterial outer membranes using all-atom molecular dynamics [PDF]
, 2022 Biological membranes are fundamental components of living organisms that play an undeniable role in their survival. Molecular dynamics (MD) serves as an essential computational tool for studying biomembranes on molecular and atomistic scales. The status quo of MD simulations of biomembranes studies a nanometer-sized membrane patch periodically extended
arxiv +1 more source
Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens [PDF]
, 2019 The lungs of patients with cystic fibrosis (CF) are colonised by a microbial community comprised of pathogenic species, such as Pseudomonas aeruginosa and Staphylococcus aureus, and microorganisms that are typically not associated with worse clinical ...
Coenye, Tom +3 more
core +1 more source