Results 81 to 90 of about 233,159 (238)

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source

Evaluation of prevalence and antibiogram of multi drug resistant, extensively drug resistant and pan drug resistant Pseudomonas aeruginosa in patients visiting a tertiary care hospital in central India

CHRISMED Journal of Health and Research, 2014
Introduction: Antibiotic resistance is an increasing concern worldwide, specially in Gram negative bacilli where there is a paucity of new and effective antimicrobial agents.
Gunjan Shrivastava, G S Bhatambare, K B Patel   +2 more
doaj   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection

Infection and Drug Resistance, 2023
Qian Qi,1,2,* Jiawei Xu,1,2,* Yujiao Wang,3,* Jian Zhang,1 Mingxia Gao,1 Yu Li,4 Liang Dong1,2 1Department of Respiratory, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong ...
Qi Q, Xu J, Wang Y, Zhang J, Gao M, Li Y, Dong L   +6 more
doaj  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Daya Hambat Ekstrak Etanol Biji Petai terhadap Bakteri Pseudomonas aeruginosa

Jurnal Ilmu Kesehatan Indonesia
Latar Belakang: Pseudomonas aeruginosa adalah penyebab umum dari infeksi nosokomial. Meningkatnya angka Multidrug resistant Pseudomonas aeruginosa menyebabkan terjadinya peningkatan biaya pengobatan sehingga diperlukan pengobatan alternatif murah dan ...
Mario Arya Ramadhan, Yustini Alioes, Andani Eka Putra, Netti Suharti, Gestina Aliska, Hasmiwati Hasmiwati   +5 more
doaj   +1 more source

Measurement and evaluation of the effects of pH gradients on the antimicrobial and antivirulence activities of chitosan nanoparticles in Pseudomonas aeruginosa

Saudi Pharmaceutical Journal, 2018
Objective: The purpose of this study was to study the antimicrobial activity of chitosan nanoparticles (CSNPs) on Pseudomonas aeruginosa with special emphasis on their sensitivity to pH and the effect of pH on their activity.
Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Gamal Shazly, Rihaf Alfaraj, Ibrahim Alsarra, Aws Alshamsan, Hosam Gareeb Abdulhady   +6 more
doaj   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source