“Resistance Is Futile”: A Pilot Study into Pseudoresistance in Canine Epilepsy [PDF]
Animals, 2023 Epilepsy is a common neurological disorder in veterinary practice, complicated by frequent occurrence of medication-resistant epilepsy. In human medicine, it has been noted that some patients with medication-resistant epilepsy have in fact other reasons ...
Marios Charalambous, Filip Kajin
exaly +7 more sources
Metabolomics and Precision Medicine in Resistant Hypertension: Pathophysiological Insights, Biomarker Discovery, and Translational Strategies [PDF]
International Journal of HypertensionResistant hypertension (RH), defined as uncontrolled blood pressure despite the use of at least three optimally dosed antihypertensive agents, including a diuretic, remains a major clinical challenge associated with elevated cardiovascular risk ...
Yu Ra Lee +3 more
doaj +3 more sources
Scabies Treatment Failure: Beyond Drug Resistance and Toward a Multidimensional Understanding [PDF]
Journal of Tropical MedicineScabies, caused by Sarcoptes scabiei var. hominis, remains a major global health problem affecting both resource-poor and high-income regions. Despite the availability of effective treatments, treatment failure continues to pose a challenge to disease ...
Jacob Al-Dabbagh
doaj +3 more sources
Seizure control in mono- and combination therapy in a cohort of patients with Idiopathic Generalized Epilepsy [PDF]
Scientific Reports, 2022 Idiopathic Generalized Epilepsy (IGE) patients may not achieve optimal seizure control with monotherapy. Our goal was to evaluate the efficacy of combination therapy in a retrospective series of IGE patients receiving different antiseizure medication ...
Leonardo Zumerkorn Pipek +2 more
doaj +2 more sources
Case Report: ALK rearranged locally advanced lung adenocarcinoma showing inconsistent radiographic findings and pathological responses during neoadjuvant alectinib therapy [PDF]
Frontiers in Pharmacology, 2023 Alectinib has been approved as first-line treatment for anaplastic lymphoma kinase (ALK)-positive non-small cell lung carcinoma. Oncologists are also exploring the possibility of applying alectinib in the perioperative period.
Peijun Cao +11 more
doaj +2 more sources
The Road to Better Management in Resistant Hypertension—Diagnostic and Therapeutic Insights
Pharmaceutics, 2021 Resistant hypertension (R-HTN) implies a higher mortality and morbidity compared to non-R-HTN due to increased cardiovascular risk and associated adverse outcomes—greater risk of developing chronic kidney disease, heart failure, stroke and myocardial ...
Elisabeta Bádila +2 more
exaly +3 more sources
Resistant Hypertension: Integration of Novel Agents and Interventional Approaches in Clinical Practice [PDF]
Reviews in Cardiovascular MedicineResistant hypertension (RH) is a high-risk phenotype characterized by blood pressure readings ≥130/80 mmHg despite maximally tolerated therapy with three antihypertensive agents, including a diuretic, or controlled blood pressure requiring four or more ...
Jose Arriola-Montenegro +12 more
doaj +2 more sources
Seizure relapse in new onset epilepsy: It is not always drug resistance. [PDF]
EpilepsiaAbstract Objective Seizure recurrence in new onset epilepsy (NOE) can result from various factors. Although drug ineffectiveness is frequently investigated, other causes—such as nonadherence, inadequate treatment, nonepileptic events (e.g., functional/dissociative), or acute symptomatic seizures—also impact patient outcomes.
Catania C +11 more
europepmc +2 more sources
Characterizing Alzheimer's Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record-Based Data. [PDF]
Clin Pharmacol TherHypertension is a known modifiable risk factor for Alzheimer’s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD.
Jafari EA +6 more
europepmc +2 more sources
Corrigendum: Resistance and pseudo-resistance to permethrin phenomena: the importance of controlling scabies [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Fabio Rinaldi +3 more
doaj +2 more sources