Results 61 to 70 of about 15,126 (225)

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network [PDF]

, 2015
The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states
Andrade, Katia C., Araujo, Draulio B. de, Crippa, Jose Alexandre S., Hallak, Jaime E. C., Palhano-Fontes, Fernanda, Ribeiro, Sidarta, Santos, Antonio C., Tofoli, Luis F.   +7 more
core   +6 more sources

Psilocybin desynchronizes brain networks

, 2023
1SummaryThe relationship between the acute effects of psychedelics and their persisting neurobiological and psychological effects is poorly understood. Here, we tracked brain changes with longitudinal precision functional mapping in healthy adults before, during, and for up to 3 weeks after oral psilocybin and methylphenidate (17 MRI visits per ...
Joshua S Siegel, Subha Subramanian, Demetrius Perry, Benjamin Kay, Evan Gordon, Timothy Laumann, Rick Reneau, Caterina Gratton, Christine Horan, Nicholas Metcalf, Ravi Chacko, Julie Schweiger, Dean Wong, David Bender, Jonah Padawer-Curry, Charles Raison, Marcus Raichle, Eric J. Lenze, Abraham Z Snyder, Nico U.F. Dosenbach, Ginger Nicol   +20 more
openaire   +2 more sources

A Longitudinal Assessment of Endometriosis Patients Prescribed Cannabis‐Based Medicinal Products: A Case Series From the UK Medical Cannabis Registry

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Although there is growing evidence supporting the use of cannabis‐based medicinal products (CBMPs) for the management of chronic pain, there is a paucity of data on their effect on endometriosis‐associated chronic pain. Aims This study aimed to perform an analysis of pain‐specific and general health‐related quality of life (HRQoL ...
Sara Getter, Simon Erridge, John Warner‐Levy, Evonne Clarke, Katy McLachlan, Ross Coomber, Shelley Barnes, Alia Darweish Medniuk, Rahul Guru, Wendy Holden, Mohammed Sajad, Robert Searle, Azfer Usmani, Sanjay Varma, James J. Rucker, Michael Platt, Mikael H. Sodergren   +16 more
wiley   +1 more source

What Neuroimaging of the Psychedelic State Tells Us about the Mind-Body Problem [PDF]

, 2016
Recent neuroimaging studies of the psychedelic state, which have commanded great media attention, are reviewed. They show that psychedelic trances are consistently accompanied by broad reductions in brain activity, despite their experiential richness ...
Kastrup, Bernardo
core  

Creativity and psychoactive substance use: a systematic review [PDF]

, 2017
The role of psychoactive substance use in the research of artistic creation and creativity is a long-standing topic. Ever since the discovery of LSD, researchers have examined the relationship between the effects of chemical substances and the artistic ...
Demetrovics, Z, Griffiths, MD, Iszáj, F
core   +1 more source

Safety pharmacology of acute mescaline administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber, Mélusine Humbert‐Droz, Laura Ley, Yasmin Schmid, Matthias E. Liechti   +4 more
wiley   +1 more source

Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

Translational Psychiatry, 2022
Psilocybin and other serotonergic psychedelics have re-emerged as therapeutics for neuropsychiatric disorders, including addiction. Psilocybin induces long-lasting effects on behavior, likely due to its profound ability to alter consciousness and augment
Nicole Fadahunsi, Jens Lund, Alberte Wollesen Breum, Cecilie Vad Mathiesen, Isabella Beck Larsen, Gitte Moos Knudsen, Anders Bue Klein, Christoffer Clemmensen   +7 more
doaj   +1 more source

Self-Transcendence Correlates with Brain Function Impairment [PDF]

, 2017
A broad pattern of correlations between mechanisms of brain function impairment and self-transcendence is shown. The pattern includes such mechanisms as cerebral hypoxia, physiological stress, transcranial magnetic stimulation, trance-induced ...
Kastrup, Bernardo
core  

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source