Results 1 to 10 of about 38,559 (244)
Unifying Theories of Psychedelic Drug Effects
Frontiers in Pharmacology, 2018 How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies?
Link R. Swanson +2 more
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Current Biology, 2022 Psychedelics are compounds that alter consciousness by acting on serotonin receptors in the brain. The term 'psychedelic', from the Greek for mind manifesting, refers to the drugs' subjective effects and was first proposed by Humphry Osmond in 1956. Other terms have been used to emphasize different aspects of the psychological experiences produced by ...
Benjamin, Kelmendi +3 more
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Case analysis of long-term negative psychological responses to psychedelics
Scientific Reports, 2023 Recent controversies have arisen regarding claims of uncritical positive regard and hype surrounding psychedelic drugs and their therapeutic potential. Criticisms have included that study designs and reporting styles bias positive over negative outcomes.
Rebecka Bremler +4 more
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Effects of psilocybin versus escitalopram on rumination and thought suppression in depression
BJPsych Open, 2022 Background Major depressive disorder is often associated with maladaptive coping strategies, including rumination and thought suppression. Aims To assess the comparative effect of the selective serotonin reuptake inhibitor escitalopram, and the ...
Tommaso Barba +8 more
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Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
Scientific Reports, 2021 Psychedelic microdosing describes the ingestion of near-threshold perceptible doses of classic psychedelic substances. Anecdotal reports and observational studies suggest that microdosing may promote positive mood and well-being, but recent placebo ...
L. S. Kaertner +9 more
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Scientific Reports, 2023 In medical trials, ‘blinding’ ensures the equal distribution of expectancy effects between treatment arms in theory; however, blinding often fails in practice.
Balázs Szigeti +3 more
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Frontiers in Psychiatry, 2022 Survey-based studies suggest naturalistic psychedelic use provides mental health benefits similar to those observed in clinical trials. The current study sought to confirm these findings in a large group of psychedelic users and to conduct a novel ...
Charles L. Raison +4 more
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Psychedelics and Psychedelic-Assisted Psychotherapy
American Journal of Psychiatry, 2020 The authors provide an evidenced-based summary of the literature on the clinical application of psychedelic drugs in psychiatric disorders.Searches of PubMed and PsycINFO via Ovid were conducted for articles in English, in peer-reviewed journals, reporting on "psilocybin," "lysergic acid diethylamide," "LSD," "ayahuasca," "3,4 ...
Collin M, Reiff +7 more
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Scientific Reports, 2023 Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). These challenging experiences contribute to hesitancy toward psychedelic-assisted psychotherapy among health
Richard J. Zeifman +7 more
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Pharmacological Reviews, 2016 Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter perception and mood and affect numerous cognitive processes. They are generally considered physiologically safe and do not lead to dependence or addiction. Their origin predates written history, and they were employed by early cultures in many sociocultural and ...
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