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Naturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit–Risk Considerations in Policy and Clinical Development [PDF]

Biomolecules
Naturally derived psilocybin is widely used, yet its therapeutic potential, pharmacological distinctiveness and regulatory feasibility remain understudied.
Stefanie Enriquez-Geppert, Lisa Bevers, Arvid Rosander, Peter Fodran, Vince Polito   +4 more
doaj   +2 more sources

Cystathionine Gamma-Lyase Regulate Psilocybin Biosynthesis in Gymnopilus dilepis Mushroom via Amino Acid Metabolism Pathways

Journal of Fungi, 2022
As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to ...
Sen Yao, Chuanzheng Wei, Hui Lin, Peng Zhang, Yuanyuan Liu, Youjin Deng, Qianhui Huang, Baogui Xie   +7 more
doaj   +1 more source

Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing: results from a prospective, longitudinal survey

Frontiers in Psychiatry, 2023
IntroductionThe classic psychedelic psilocybin, found in some mushroom species, has received renewed interest in clinical research, showing potential mental health benefits in preliminary trials.
Sandeep M. Nayak, Sandeep M. Nayak, Hillary Jackson, Hillary Jackson, Nathan D. Sepeda, Nathan D. Sepeda, Nathan D. Sepeda, David S. Mathai, David S. Mathai, Sara So, Sara So, Abigail Yaffe, Abigail Yaffe, Hadi Zaki, Hadi Zaki, Trey J. Brasher, Matthew X. Lowe, Del R. P. Jolly, Frederick S. Barrett, Frederick S. Barrett, Frederick S. Barrett, Frederick S. Barrett, Roland R. Griffiths, Roland R. Griffiths, Roland R. Griffiths, Justin C. Strickland, Justin C. Strickland, Matthew W. Johnson, Heather Jackson, Albert Garcia-Romeu, Albert Garcia-Romeu   +30 more
doaj   +1 more source

Association of Psilocybin Use in Adolescents with Major Depressive Episode

European Psychiatry, 2022
Introduction Psilocybin is a psychedelic drug found in mushrooms, often referred to as magic mushrooms due to its visual and auditory hallucinations effects upon ingestion.
K. Shah, C. Trivedi, D. Kamrai, M. Akbar, W. Tankersley   +4 more
doaj   +1 more source

Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls

Scientific Reports, 2022
Psilocybin microdosing involves repeated self-administration of mushrooms containing psilocybin at doses small enough to not impact regular functioning. Microdose practices are diverse and include combining psilocybin with substances such as lion’s mane ...
Joseph M. Rootman, Maggie Kiraga, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P. C. Kuypers, Zach Walsh   +7 more
doaj   +1 more source

Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats

Translational Psychiatry, 2023
Alcohol Use Disorder (AUD) adversely affects the lives of millions of people, but still lacks effective treatment options. Recent advancements in psychedelic research suggest psilocybin to be potentially efficacious for AUD. However, major knowledge gaps
Jonathan R. Reinwald, Christian N. Schmitz, Ivan Skorodumov, Martin Kuchar, Wolfgang Weber-Fahr, Rainer Spanagel, Marcus W. Meinhardt   +6 more
doaj   +1 more source

Psilocybin sex-dependently reduces alcohol consumption in C57BL/6J mice

Frontiers in Pharmacology, 2023
The classical psychedelic psilocybin is of interest as a treatment for alcohol use disorder (AUD). This study investigated the effects of psilocybin on voluntary ethanol consumption in adult male and female C57BL/6J mice administered saline or psilocybin
Kenneth Alper, Kenneth Alper, Janelle Cange, Ria Sah, Deanna Schreiber-Gregory, Henry Sershen, Henry Sershen, K. Yaragudri Vinod, K. Yaragudri Vinod, K. Yaragudri Vinod   +9 more
doaj   +1 more source

Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder

Translational Psychiatry, 2023
Preliminary clinical findings, supported by preclinical studies employing behavioral paradigms such as marble burying, suggest that psilocybin may be effective in treating obsessive-compulsive disorder.
Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschytz   +9 more
doaj   +1 more source

Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial

BJPsych Open, 2023
Background Randomised controlled trials (RCTs) of psilocybin have reported large antidepressant effects in adults with major depressive disorder and treatment-resistant depression (TRD).
Muhammad Ishrat Husain, Daniel M. Blumberger, David J. Castle, Nicole Ledwos, Elise Fellows, Brett D. M. Jones, Abigail Ortiz, Stefan Kloiber, Wei Wang, Joshua D. Rosenblat, Benoit H. Mulsant   +10 more
doaj   +1 more source

Psilocybin-Assisted Compassion Focused Therapy for Depression

Frontiers in Psychology, 2022
Psilocybin-assisted psychotherapy, i.e., psilocybin treatment with psychological support, has demonstrated the efficacy of psilocybin to reduce depressive symptoms.
Wendy Pots, Farid Chakhssi
doaj   +1 more source