Contribution of the Serotonin 5‐HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress [PDF]
Neuropsychopharmacology ReportsPsychedelics such as psilocybin and lysergic acid diethylamide (LSD) exert hallucinogenic effects through stimulation of serotonin 5‐HT2A receptors (5‐HT2ARs) in the cerebral cortex.
Daisuke Ibi +10 more
doaj +3 more sources
Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons [PDF]
eLifePsilocybin is studied as innovative medication in anxiety, substance abuse and treatment-resistant depression. Animal studies show that psychedelics promote neuronal plasticity by strengthening synaptic responses and protein synthesis. However, the exact
Malin Schmidt +9 more
doaj +5 more sources
DESI-MSI-Based Multi-Organ Distribution Mapping of Psilocin in Zebrafish [PDF]
MoleculesPsilocybin, a psychedelic drug with reported anxiolytic and antidepressant potential, is rapidly metabolized to its active metabolite psilocin. However, a lack of adequate toxicity studies and tissue distribution studies currently restricts its ...
Mengxuan Dong +6 more
doaj +4 more sources
Sex-specific increased reactivity of the PVT and prolonged PVT→CeA circuit engagement following psilocin administration [PDF]
Nature CommunicationsThe psychedelic psilocybin has shown therapeutic potential, yet underlying neural mechanisms remain poorly understood. We investigated the impact of psilocin—the active metabolite of psilocybin—on basal activity and reactivity within the paraventricular ...
D. P. Effinger +8 more
doaj +4 more sources
Acute psilocin increased cortical activity in rat [PDF]
Frontiers in NeurosciencePsilocin, a naturally occurring hallucinogenic component of magic mushrooms, exerts notable psychoactive effects in both humans and rodents. However, the underlying mechanisms remain not fully understood.
Junhong Liu +8 more
doaj +4 more sources
Toxins, 2015 The pharmacological activities and acute toxicity of the psilocin (PC) and dried residues of the crude extracts of psychotropic mushrooms were investigated in mice.
Izabela Jasicka-Misiak +2 more
exaly +3 more sources
A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study to Identify a Subperceptual Dose of Psilocybin in Healthy Adults [PDF]
PharmaceuticalsBackground/Objectives: Psilocybin shows therapeutic promise for several psychiatric disorders, but the acute perceptual and cognitive alterations produced by conventional doses (10–25 mg) require in-clinic supervision, which limits scalability.
Naama Levy-Cooperman +7 more
doaj +2 more sources
Safety and Efficacy of Natural and Conventional Psychiatric Treatments: A Comparative Review of Mushroom-Derived Compounds and Medicinal Plants in the Management of Mental Disorders [PDF]
MoleculesStandard pharmacotherapy for mental disorders, including depression and anxiety, is supported by extensive clinical validation and international treatment guidelines. However, it is frequently associated with limitations such as adverse side effects, low
Katarzyna Gawłowska +8 more
doaj +2 more sources
Effects of Psilocin and Psilocybin on Human 5-HT4 Serotonin and H2 Histamine Receptors in Perfused Hearts of Transgenic Mice [PDF]
PharmaceuticalsBackground/Objectives: Hallucinogenic substances such as psilocybin, psilocin, ergometrine, ergotamine, and lysergic acid diethylamide (LSD) have been demonstrated to enhance the force of contraction (FOC), in part due to the phosphorylation of ...
Pauline Braekow +3 more
doaj +2 more sources
eLifeHuman neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.
Jessica L Maltman +1 more
doaj +2 more sources