Results 41 to 50 of about 2,211 (199)

Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications. [PDF]

Pharmaceuticals (Basel)
The growing body of evidence supporting the therapeutic efficacy of psychoactive substances, like psilocybin, has driven significant interest in recent decades due to their low toxicity and potential applications in treating various mental health ...
Galdino TP, Oliveira LC, Luz MA, Jesus RA, Lima EPN, Torres MCM, Sivieri K, Afonso VI, Delgado JMPQ, Lima AGB, Silva SML, Fook MVL.   +11 more
europepmc   +2 more sources

Efficient Acyloxymethylation of Psilocin and Other Tryptamines Yielding ACOM Prodrugs for Psychedelic-Assisted Therapy. [PDF]

Arch Pharm (Weinheim)
Acyloxymethyl (ACOM) derivatives of tryptamines such as the psychedelic drug psilocin and the anti‐migraine drug sumatriptan bear potential as prodrugs.
Stirn J, Klein CD.
europepmc   +2 more sources

Preparation of the 4-Hydroxytryptamine Scaffold via Palladium-Catalyzed Cyclization:  A Practical and Versatile Synthesis of Psilocin

, 2016
The 4-hydroxytryptamine scaffold of psilocin was successfully prepared via palladium-catalyzed cyclization of protected N-tert-butoxycarbonyl-2-iodo-3-methoxyaniline and an appropriately substituted silyl acetylene.
Nicholas Gathergood (1803943), Peter J. Scammells (694050)   +1 more
core   +2 more sources

Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-Glucuronosyltransferases [PDF]

Drug Metabolism and Disposition, 2010
We have examined the glucuronidation of psilocin, a hallucinogenic indole alkaloid, by the 19 recombinant human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B. The glucuronidation of 4-hydroxyindole, a related indole that lacks the N,N-dimethylaminoethyl side chain, was studied as well.
MANEVSKI, Nenad, KURKELA, Mika, HÖGLUND, Camilla, MAURIALA, Timo, COURT, Michael H, YLI-KAUHALUOMA, Jari, FINEL, Moshe   +6 more
openaire   +3 more sources

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, EarlyView.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source

Evaluation of illicit drug contaminants in seized cannabis in Arizona and California, 2023–2024

Journal of Forensic Sciences, EarlyView.
Abstract Despite public health concerns, fentanyl, cocaine, and other illicit drug contaminants remain largely understudied in unregulated cannabis. Here, we developed an analytical method to quantify a panel of common illicit drugs in cannabis and tested the law enforcement seizures in Arizona and California in evaluation of the illicit drug ...
Beckner Andersano, Thomas M. Cahill, Michael Grommes, Maxwell C. K. Leung   +3 more
wiley   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

DETEKSI PSILOCIN PLASMA PADA MENCIT SWISS WEBSTER TERHADAP PEMBERIAN JAMUR PSILOCYBE CUBENSIS DOSIS BERTINGKAT [PDF]

, 2013
Latar Belakang Salah satu jamur Psilocybin yang memberikan efek halusinasi yaitu Psilocybe cubensis. Terdapat bermacam-macam senyawa yang terkandung didalamnya,salah satunya adalah psilocin.
Dahanardhono, Tuntas, Syahreza, Satri, Bima, Sigit Kirana Lintang   +2 more
core  

Psilocybin in alcohol use disorder and comorbid depressive symptoms: Results from a feasibility randomized clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted
Amandine Luquiens, Dahbia Belahda, Carine Graux, Noe Igounenc, Chris Serrand, Paul Rochefort, Thibault Mura, Felix Sergent   +7 more
wiley   +1 more source