Results 41 to 50 of about 2,780 (214)

Rediscovering Psilocybin as an Antidepressive Treatment Strategy

Pharmaceuticals, 2021
There has recently been a renewal of interest in psychedelic research on the use of psilocybin in psychiatric treatment and, in particular, for the treatment of major depressive disorder (MDD).
Rene Zeiss, Maximilian Gahr, Heiko Graf
doaj   +1 more source

Novel Psychoactive Substances: : the pharmacology of stimulants and hallucinogens [PDF]

, 2016
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Clinical Pharmacology, on March 2016, available online at doi: : http://www.tandfonline.com/doi/full/10.1586/17512433.2016.1167597.There are increasing levels ...
Corkery JM, Daly M, Dargan PI, Fabrizio Schifano, Farrè M, G. Duccio Papanti, John M. Corkery, Laura Orsolini, Shulgin AT, Shulgin AT, Soussan C, Ujváry I   +11 more
core   +3 more sources

In vivo validation of psilacetin as a prodrug yielding modestly lower peripheral psilocin exposure than psilocybin

Frontiers in Psychiatry
IntroductionThe use of the psychedelic compound psilocybin in conjunction with psychotherapy has shown promising results in the treatment of psychiatric disorders, though the underlying mechanisms supporting these effects remain unclear.
Nathan T. Jones, Laura Wagner, Molly C. Pellitteri Hahn, Cameron O. Scarlett, Cody J. Wenthur   +4 more
doaj   +1 more source

Semantic activation in LSD: evidence from picture naming [PDF]

, 2016
Lysergic acid diethylamide (LSD) is a classic psychedelic drug that alters cognition in a characteristic way. It has been suggested that psychedelics expand the breadth of cognition via actions on the central nervous system.
Bolstridge, M, Carhart-Harris, RL, Family, N, Kaelen, M, Nutt, DJ, Vigliocco, G, Vinson, D   +6 more
core   +1 more source

Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats

Frontiers in Neuroscience, 2023
IntroductionPsilocybin is one of the most extensively studied psychedelic drugs with a broad therapeutic potential. Despite the fact that its psychoactivity is mainly attributed to the agonism at 5-HT2A receptors, it has high binding affinity also to 5 ...
Filip Tylš, Filip Tylš, Čestmír Vejmola, Čestmír Vejmola, Vlastimil Koudelka, Václava Piorecká, Václava Piorecká, Lukáš Kadeřábek, Marcel Bochin, Marcel Bochin, Tomáš Novák, Tomáš Novák, Martin Kuchař, Martin Kuchař, Zdeňka Bendová, Martin Brunovský, Martin Brunovský, Jiří Horáček, Jiří Horáček, Tomáš Pálení ček, Tomáš Pálení ček   +20 more
doaj   +1 more source

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

Frontiers in Pharmacology
In vivo, psilocybin is rapidly dephosphorylated to psilocin which induces psychedelic effects by interacting with the 5-HT2A receptor. Psilocin primarily undergoes glucuronidation or conversion to 4-hydroxyindole-3-acetic acid (4-HIAA).
Jan Thomann, Jan Thomann, Karolina E. Kolaczynska, Karolina E. Kolaczynska, Oliver V. Stoeckmann, Oliver V. Stoeckmann, Deborah Rudin, Deborah Rudin, Patrick Vizeli, Patrick Vizeli, Marius C. Hoener, Christopher R. Pryce, Franz X. Vollenweider, Matthias E. Liechti, Matthias E. Liechti, Urs Duthaler, Urs Duthaler, Urs Duthaler, Urs Duthaler   +18 more
doaj   +1 more source

In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 Receptor

Frontiers in Immunology, 2022
Various metabolites identified with therapeutic mushrooms have been found from different sources and are known to have antibacterial, antiviral, and anticancer properties.
Faez Iqbal Khan, Fakhrul Hassan, Dakun Lai   +2 more
doaj   +1 more source

The beast initiate: the lycanthropy of Heracles [PDF]

, 2019
The obscurantist Hellenistic poet Lycophron referenced the initiation of Heracles as a beast suckling the breast of the goddess Hera. This was the event that was the mythological origin of the Galaxy and of the lily flower that incarnated the same ...
Ruck, Carl
core   +2 more sources

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation

Angewandte Chemie International Edition, EarlyView.
The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner, Kai Rogge, Felix Trottmann, Christian Hertweck, Dirk Hoffmeister   +4 more
wiley   +1 more source

Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects

NeuroImage, 2022
Background: Psilocin, the neuroactive metabolite of psilocybin, is a serotonergic psychedelic that induces an acute altered state of consciousness, evokes lasting changes in mood and personality in healthy individuals, and has potential as an ...
Anders S. Olsen, Anders Lykkebo-Valløe, Brice Ozenne, Martin K. Madsen, Dea S. Stenbæk, Sophia Armand, Morten Mørup, Melanie Ganz, Gitte M. Knudsen, Patrick M. Fisher   +9 more
doaj   +1 more source