Results 21 to 30 of about 2,121 (171)

Surprising Variability in Tryptamine Profiles of Psilocybe cubensis Fruiting Bodies: Inter- and Intra-Strain Differences Across 14 Strains Cultivated Under Controlled Conditions [PDF]

Journal of Fungi
Psilocybin-producing mushrooms exhibit considerable biochemical diversity, yet the extent of variability among strains within a single species under standardized conditions remains insufficiently characterized.
Amiel Sharchaton, Shilat Parsha, Sara P. Azerrad, Yaron Dekel, Nisreen Rabah, Tomáš Páleníček, Eyal Kurzbaum   +6 more
doaj   +2 more sources

828. Psilocin attenuates polyinosinic:polycytidylic acid (Poly I:C)-indued interferon responses in human peripheral blood mononuclear cells [PDF]

Int J Neuropsychopharmacol
Christopher Sheridan, Guillaume Thuery, K Brennan, Patricia Iusan, John Richard Kelly, Andrew Harkin   +5 more
europepmc   +3 more sources

475. Psilocin pharmacokinetics and exposure-response relationships in Japanese patients with treatment-resistant depression receiving psilocybin therapy: an open-label study [PDF]

Int J Neuropsychopharmacol
K Kusudo, K Yonezawa, S Tomiyama, L Harada, Takeshi Akiyoshi, H Ohtani, K Suzuki, D Stoliker, S Nakajima, H Tani, H Uchida   +10 more
europepmc   +3 more sources

Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT₂ Receptor-Dependent Manner

Molecules
Neuroinflammation that is caused by microglia, the main immune cells of the brain, contributes to neurodegenerative diseases. Psychedelics, including psilocybin and lysergic acid diethylamide (LSD), possess certain anti-inflammatory properties and ...
Kennedy R. Wiens, Noah A. H. Brooks, Ishvin Riar, Bridget K. Greuel, Ivan A. Lindhout, Andis Klegeris   +5 more
doaj   +2 more sources

Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation [PDF]

Translational Psychiatry
Psilocybin, and its active metabolite psilocin, have seen renewed interest due to studies suggesting potential therapeutic utility. 5-Hydroxytryptamine2A receptors (5-HT2ARs) are primary mediators of the psychoactive effects of psychedelics in animals ...
Gavin P. Schmitz, Yi-Ting Chiu, Mia L. Foglesong, Sarah N. Magee, Martin MacKinnon, Gabriele M. König, Evi Kostenis, Li-Ming Hsu, Yen-Yu I. Shih, Bryan L. Roth, Melissa A. Herman   +10 more
doaj   +2 more sources

Development of a Microcrystal Test For The Detection of Psilocin [PDF]

, 2019
A microcrystal test is a chemical reaction at a microscopic level, which was developed in the 1800’s as a way to identify unknown alkaloids. Recently this type of testing has been experiencing a revival within forensic science due in part to the rise in ...
Jacqueline Davila (7976654)
core   +7 more sources

A randomized crossover trial comparing the acute physiological and psychological effects of botanical formulations of oral psilocybin, oral psilocin, and sublingual psilocin

Background: Psilocybin, a serotonergic psychedelic found in hallucinogenic mushrooms, is metabolized to psilocin, the compound responsible for its psychoactive effects.
Marlene L. Tai, Balázs Szigeti, Amanda E. Downey, Jacob S. Aday, Lisa Fredenburg, Kimberly Sakai, Cesar Molina, Gisele Fernandes‐Osterhold, Ellen R. Bradley, Madeline M. Pantoni, Ryan Kurtis Moss, Benjamin Lightburn, Franziska Plessow, Aoife O’Donovan, Joshua D. Woolley   +14 more
openalex   +2 more sources

Psilocin glucuronide in whole blood: a stable and useful biomarker of psilocybin intake. [PDF]

J Anal Toxicol
Bergh MS, Bogen IL, Vevelstad M, Øiestad ÅML.   +3 more
europepmc   +2 more sources

The effect of psilocin on neurotransmitters release in the claustrum and on rat behavior. [PDF]

Pharmacol Rep
Kościuk Z, Szpręgiel I, Bysiek A, Gołembiowska K.   +3 more
europepmc   +3 more sources

Sex-specific effects of psychedelic drug exposure on central amygdala reactivity and behavioral responding

Translational Psychiatry, 2023
Psilocybin and its active metabolite psilocin have been shown to elicit rapid and long-lasting symptom improvements in a variety of affective psychiatric illnesses.
D. P. Effinger, S. G. Quadir, M. C. Ramage, M. G. Cone, M. A. Herman   +4 more
doaj   +1 more source