Results 21 to 30 of about 2,211 (199)

The effect of psilocin on neurotransmitters release in the claustrum and on rat behavior. [PDF]

Pharmacol Rep
The claustrum, a subcortical structure densely expressing 5-hydroxytryptamine 2 A (5-HT2A) receptors, has been implicated in sensory integration, emotional regulation, salience, and attention.
Kościuk Z, Szpręgiel I, Bysiek A, Gołembiowska K.   +3 more
europepmc   +4 more sources

Novel Psilocin Prodrugs with Altered Pharmacological Properties as Candidate Therapies for Treatment-Resistant Anxiety Disorders

bioRxiv, 2023
The psychedelic prodrug psilocybin has shown therapeutic benefits for the treatment of numerous psychiatric conditions. Despite positive clinical end points targeting depression and anxiety, concerns regarding the duration of the psychedelic experience ...
Lisa Yu (245028), Glynnis Jensen (17419852), Peter J. Facchini (711549), Jillian M. Hagel (14564740), David Press (17419840), Jaideep Bains (17419861), Joseph E. Tucker (17419864), Govinda Sharma (17419846), Jonathan Gallant (17419858), Kaveh Matinkhoo (4990370), Sarah G. Cook (17419843), Jessica B. Lee (4372180), D. Dhananjaya (17419849), Sheetal A. Raithatha (17419837), Charlie Cai (17419855)   +14 more
core   +3 more sources

Acute psilocin increased cortical activity in rat. [PDF]

Front Neurosci
Psilocin, a naturally occurring hallucinogenic component of magic mushrooms, exerts notable psychoactive effects in both humans and rodents. However, the underlying mechanisms remain not fully understood. Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is a valuable tool in many preclinical and clinical trials for ...
Liu J, Wang Y, Xia K, Wu J, Zheng D, Cai A, Yan H, Su R.   +7 more
europepmc   +2 more sources

Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance

Drug Metabolism Reviews, 2017
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)2A subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic relevance but considerable physiological ...

exaly   +4 more sources

Effects of psilocin and psilocybin on human 5-HT4 serotonin receptors in atrial preparations of transgenic mice and humans [PDF]

Toxicology Letters
Several fungi belonging to the genus Psilocybe, also called “magic mushrooms”, contain the hallucinogenic drugs psilocybin and psilocin. They are chemically related to serotonin (5-HT).
Azatsian, Karyna, Hofmann, Britt, Gergs, Ulrich, Dimov, Kiril, Neumann, Joachim   +4 more
core   +2 more sources

Increased reactivity of the paraventricular nucleus of the hypothalamus and decreased threat responding in male rats following psilocin administration

Nature Communications
Psychedelics have experienced renewed interest following positive clinical effects, however the neurobiological mechanisms underlying effects remain unclear. The paraventricular nucleus of the hypothalamus (PVN) plays an integral role in stress response,
Quadir, Sema G., Magee, Sarah N., High, Margaret W., Hoffman, Jessica L., Effinger, Devin P., Echeveste Sanchez, Maria, Mott, Sarah E., Rollison, Christian S., Toedt, Daniel, Hodge, Clyde W., Herman, Melissa A.   +10 more
core   +3 more sources

Research on Acute Toxicity and the Behavioral Effects of Methanolic Extract from Psilocybin Mushrooms and Psilocin in Mice

Toxins, 2015
The pharmacological activities and acute toxicity of the psilocin (PC) and dried residues of the crude extracts of psychotropic mushrooms were investigated in mice.
Izabela Jasicka-Misiak, Anna Poliwoda, Piotr P Wieczorek   +2 more
exaly   +2 more sources

Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT2 Receptor-Dependent Manner

Molecules
Neuroinflammation that is caused by microglia, the main immune cells of the brain, contributes to neurodegenerative diseases. Psychedelics, including psilocybin and lysergic acid diethylamide (LSD), possess certain anti-inflammatory properties and ...
Noah A. H. Brooks, Ivan A. Lindhout, Andis Klegeris, Brooks, Noah A. H., Greuel, Bridget K., Ishvin Riar, Wiens, Kennedy R., Klegeris, Andis, Kennedy R. Wiens, Bridget K. Greuel, Riar, Ishvin, Lindhout, Ivan   +11 more
core   +2 more sources

Determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection respectively

Talanta, 2005
A simple, rapid and sensitive method for the determination of psilocin and psilocybin is described. This is the first report on the determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2 ...
Simon W Lewis, Nicholas Gathergood, Neil W Barnett   +2 more
exaly   +1 more source

The Medial Prefrontal Cortex Modulates Psychedelic-like Effects of Psilocin

ACS Pharmacology & Translational Science
Recent advancements in the study of psilocybin and its active metabolite psilocin have highlighted their unique psychedelic properties and potential therapeutic applications, particularly in the rapid and sustained treatment of depression. However, the potent acute psychedelic effects of psilocybin necessitate a deeper understanding of the neural ...
Miyuan Zhang, Haojiang Zhai, Longwei Yang, Haohong Li, Xiaohui Wang   +4 more
openaire   +4 more sources