Results 11 to 20 of about 2,211 (199)

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin [PDF]

Frontiers in Pharmacology
In vivo, psilocybin is rapidly dephosphorylated to psilocin which induces psychedelic effects by interacting with the 5-HT$_{2A}$ receptor. Psilocin primarily undergoes glucuronidation or conversion to 4-hydroxyindole-3-acetic acid (4-HIAA).
Stoeckmann, Oliver V, Rudin, Deborah, Hoener, Marius C, Pryce, Christopher R; https://orcid.org/, Liechti, Matthias E, Vollenweider, Franz X; https://orcid.org/, Kolaczynska, Karolina E, Thomann, Jan, Vizeli, Patrick, Duthaler, Urs   +9 more
core   +5 more sources

Synthesis and In Vitro Profiling of Psilocin Derivatives: Improved Stability and Synthetic Properties. [PDF]

J Med Chem
As interest in using psilocybin therapy for treating mental health disorders intensifies, the need for efficient production methods becomes increasingly important.
Eklund J, Bremberg U, Larsson J, Torkelsson E, Wennerberg J, Zandelin S, Odell LR.   +6 more
europepmc   +3 more sources

Development of a PBPK model of psilocybin/psilocin from Psilocybe cubensis (magic mushroom) in mice, rats, and humans. [PDF]

Sci Rep
Psilocybin is an active alkaloid found in magic mushrooms (Psilocybe cubensis). It is classified as a Class I Psychoactive Substance due to its psychoactive properties.
Thaoboonruang N, Lohitnavy O, Ya K, Lohitnavy M.   +3 more
europepmc   +3 more sources

Cross-Species Evidence for Psilocin-Induced Visual Distortions: Apparent Motion Is Perceived by Both Humans and Rats. [PDF]

Biol Psychiatry Glob Open Sci
Background: Psychedelics, particularly psilocin, are increasingly being studied for their mind-altering effects and potential therapeutic applications in psychiatry.
Vejmola Č, Šíchová K, Syrová K, Janečková L, Koudelka V, Tesař M, Nikolič M, Viktorinová M, Tylš F, Korčák J, Viktorin V, Kelemen E, Nekovářová T, Brunovský M, Horáček J, Kuchař M, Páleníček T.   +16 more
europepmc   +3 more sources

Effects of Psilocin and Psilocybin on Human 5-HT₄ Serotonin and H₂ Histamine Receptors in Perfused Hearts of Transgenic Mice. [PDF]

Pharmaceuticals (Basel)
Background/Objectives: Hallucinogenic substances such as psilocybin, psilocin, ergometrine, ergotamine, and lysergic acid diethylamide (LSD) have been demonstrated to enhance the force of contraction (FOC), in part due to the phosphorylation of ...
Braekow P, Neumann J, Kirchhefer U, Gergs U.   +3 more
europepmc   +3 more sources

Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

European Neuropsychopharmacology, 2021
The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor critically mediates these effects by altering distributed neural processes ...
Martin K Madsen, Dea Siggaard Stenbæk, Sophia Armand   +2 more
exaly   +3 more sources

The molecular basis of the antidepressant action of the magic mushroom extract, psilocin

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2023
Magic mushrooms, and their extract psilocybin, are well-known for their psychedelic properties and recreational use. Psilocin, the bio-active form of psilocybin, can potentially treat various psychiatric diseases.
Ali Asghar Hakami Zanjani, Luise Jacobsen, Himanshu Khandelia   +2 more
exaly   +2 more sources

Neurovascular and neuroimaging effects of the hallucinogenic serotonin receptor agonist psilocin in the rat brain [PDF]

Neuropharmacology, 2015
The development of pharmacological magnetic resonance imaging (phMRI) has presented the opportunity for investigation of the neurophysiological effects of drugs in vivo. Psilocin, a hallucinogen metabolised from psilocybin, was recently reported to evoke
Aisling Spain, Clare Howarth, Alexandre A Khrapitchev   +2 more
exaly   +2 more sources

The effect of psilocin on memory acquisition, retrieval and consolidation in rat. [PDF]

Frontiers in Behavioral Neuroscience, 2014
The involvement of the serotonin system in the pathophysiology of schizophrenia has been elucidated by experiments with hallucinogens. Application of a hallucinogen to humans leads to changes in perception, cognition, emotions and induction of psychotic ...
Ales Stuchlik, Lukas Rambousek, Tomas Palenicek, Tomas ePalenicek, Ales eStuchlik, Karel eVales, Lukas eRambousek, Karel Vales   +7 more
core   +4 more sources

Clinical pharmacokinetics of psilocin after psilocybin administration: a systematic review and post-hoc analysis

Clinical Pharmacokinetics
Psilocybin is currently being extensively studied as a potential therapeutic agent for multiple psychiatric disorders. Here, a systematic literature review of all published pharmacokinetic data on the pharmacologically active metabolite of psilocybin ...
Schoones, J.W., Jacobs, G.E., Esdonk, M.J. van, Heijden, K.V. van der, Otto, M.E., Borghans, L.G.J.M., Hasselt, J.G.C. van   +6 more
core   +2 more sources