Results 11 to 20 of about 2,121 (171)

Cross-Species Evidence for Psilocin-Induced Visual Distortions: Apparent Motion Is Perceived by Both Humans and Rats

Biological Psychiatry Global Open Science
Background: Psychedelics, particularly psilocin, are increasingly being studied for their mind-altering effects and potential therapeutic applications in psychiatry.
Čestmír Vejmola, Klára Šíchová, Kateřina Syrová, Lucie Janečková, Vlastimil Koudelka, Michael Tesař, Marek Nikolič, Michaela Viktorinová, Filip Tylš, Jakub Korčák, Vojtěch Viktorin, Eduard Kelemen, Tereza Nekovářová, Martin Brunovský, Jiří Horáček, Martin Kuchař, Tomáš Páleníček   +16 more
doaj   +3 more sources

Development of a PBPK model of psilocybin/psilocin from Psilocybe cubensis (magic mushroom) in mice, rats, and humans [PDF]

Scientific Reports
Psilocybin is an active alkaloid found in magic mushrooms (Psilocybe cubensis). It is classified as a Class I Psychoactive Substance due to its psychoactive properties.
Nilubon Thaoboonruang, Ornrat Lohitnavy, Kimheang Ya, Manupat Lohitnavy   +3 more
doaj   +3 more sources

The Theoretical Description for Psilocin Electrochemical Determination over Cobalt Oxyhydroxide [PDF]

Orbital: The Electronic Journal of Chemistry, 2023
The possibility of psilocin electrochemical determination over cobalt (III) oxyhydroxide-modified anode is evaluated from the mathematical point of view.
Volodymyr Tkach, Mykhailo Kucher, Marta Kushnir, Yana Ivanushko, Yüksel Akınay, Necdet Karakoyun, Petro Yagodynets, Zholt Kormosh   +7 more
doaj   +2 more sources

Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice [PDF]

Translational Psychiatry, 2022
Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N,N-dimethyltryptamine), profoundly alter the quality of consciousness through mechanisms which are incompletely understood.
Christopher W. Thomas, Cristina Blanco-Duque, Benjamin J. Bréant, Guy M. Goodwin, Trevor Sharp, David M. Bannerman, Vladyslav V. Vyazovskiy   +6 more
doaj   +2 more sources

The effect of psilocin on memory acquisition, retrieval and consolidation in rat. [PDF]

Frontiers in Behavioral Neuroscience, 2014
The involvement of the serotonin system in the pathophysiology of schizophrenia has been elucidated by experiments with hallucinogens. Application of a hallucinogen to humans leads to changes in perception, cognition, emotions and induction of psychotic ...
Lukas eRambousek, Tomas ePalenicek, Karel eVales, Ales eStuchlik   +3 more
doaj   +2 more sources

Design, Synthesis, and Pharmacokinetic Profiling of Fluorinated Reversible <i>N</i>-Alkyl Carbamate Derivatives of Psilocin for Sub-Hallucinogenic Brain Exposure. [PDF]

J Med Chem
Psilocybin, The Phosphorylated Prodrug Of Psilocin, Holds Therapeutic Promise Across A Range Of Neuropsychiatric Conditions, Yet Its Clinical Utility Is Constrained By Acute Psychoactive Effects.
Banzato M, Colognesi M, Lucatello L, Comai S, Pasut G, Capolongo F, Orian L, Biasutto L, Signor A, Gabbia D, Manfredi PL, De Martin S, Mattarei A.   +12 more
europepmc   +3 more sources

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin [PDF]

Frontiers in Pharmacology
In vivo, psilocybin is rapidly dephosphorylated to psilocin which induces psychedelic effects by interacting with the 5-HT2A receptor. Psilocin primarily undergoes glucuronidation or conversion to 4-hydroxyindole-3-acetic acid (4-HIAA).
Jan Thomann, Jan Thomann, Karolina E. Kolaczynska, Karolina E. Kolaczynska, Oliver V. Stoeckmann, Oliver V. Stoeckmann, Deborah Rudin, Deborah Rudin, Patrick Vizeli, Patrick Vizeli, Marius C. Hoener, Christopher R. Pryce, Franz X. Vollenweider, Matthias E. Liechti, Matthias E. Liechti, Urs Duthaler, Urs Duthaler, Urs Duthaler, Urs Duthaler   +18 more
doaj   +2 more sources

Novel qNMR Method to Quantify Psilocybin and Psilocin in Psychedelic Mushrooms. [PDF]

ACS Omega
Psychedelic mushrooms of the Psilocybe genus contain the psychoactive tryptamines psilocybin and psilocin, compounds currently under clinical investigation for the treatment of depression and other psychiatric conditions.
Rodríguez L, Morera G, Lupo S, Davyt D, Carrera I, Hernández Dossi G.   +5 more
europepmc   +5 more sources

Increased reactivity of the paraventricular nucleus of the hypothalamus and decreased threat responding in male rats following psilocin administration [PDF]

Nature Communications
Psychedelics have experienced renewed interest following positive clinical effects, however the neurobiological mechanisms underlying effects remain unclear. The paraventricular nucleus of the hypothalamus (PVN) plays an integral role in stress response,
Devin P. Effinger, Jessica L. Hoffman, Sarah E. Mott, Sarah N. Magee, Sema G. Quadir, Christian S. Rollison, Daniel Toedt, Maria Echeveste Sanchez, Margaret W. High, Clyde W. Hodge, Melissa A. Herman   +10 more
doaj   +3 more sources

The magic of mushrooms: psilocybin influences behavior in the mangrove rivulus fish, Kryptolebias marmoratus [PDF]

Frontiers in Behavioral Neuroscience
Non-human models, including fish, are increasingly important for investigating how pharmacological agents such as hallucinogens influence behavior, physiology, and cellular processes.
Dayna Forsyth, Nicoletta Faraone, Simon G. Lamarre, Suzanne Currie   +3 more
doaj   +2 more sources