Results 1 to 10 of about 27,791 (179)

Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential [PDF]

Nature Communications, 2023
Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT2A receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5-HT2A-Gq/11 and β-arrestin2 transducers, making their respective roles ...
Jason Wallach, Andrew B. Cao, Maggie M. Calkins, Andrew J. Heim, Janelle K. Lanham, Emma M. Bonniwell, Joseph J. Hennessey, Hailey A. Bock, Emilie I. Anderson, Alexander M. Sherwood, Hamilton Morris, Robbin de Klein, Adam K. Klein, Bruna Cuccurazzu, James Gamrat, Tilka Fannana, Randy Zauhar, Adam L. Halberstadt, John D. McCorvy   +18 more
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Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance [PDF]

Frontiers in Pharmacology, 2022
Various forms of traumatic brain injury (TBI) are a leading cause of disability in the United States, with the generation of neuropsychiatric complications such as depression, anxiety, social dysfunction, and suicidality being common comorbidities ...
Sean M. Collins, Christopher J. O’Connell, Evan L. Reeder, Sophia V. Norman, Kainat Lungani, Poornima Gopalan, Gary A. Gudelsky, Gary A. Gudelsky, Matthew J. Robson, Matthew J. Robson   +9 more
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Biased signaling via serotonin 5-HT2A receptor: From structural aspects to in vitro and in vivo pharmacology [PDF]

Acta Pharmaceutica Sinica B
G protein-coupled receptors (GPCRs) represent key drug targets, with approximately 30%–40% of all medications acting on these receptors. Recent advancements have uncovered the complexity of GPCR signaling, including biased signaling, which allows ...
Michał K. Jastrzębski, Piotr Wójcik, Angelika Grudzińska, Giorgia Andreozzi, Tommaso Vetrò, Ayesha Asim, Akanksha Mudgal, Jakub Czapiński, Tomasz M. Wróbel, Damian Bartuzi, Katarzyna M. Targowska-Duda, Agnieszka A. Kaczor   +11 more
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PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization

Frontiers in Endocrinology, 2021
Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Heterozygous Pacap mutant mice show
Atsuko Hayata-Takano, Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Takanobu Nakazawa, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto   +12 more
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Serotonin 5-HT2A receptor activity mediates adipocyte differentiation through control of adipogenic gene expression

Scientific Reports, 2021
Serotonin 5-HT2 receptors are expressed in many tissues and play important roles in biological processes. Although the 5-HT2A receptor is primarily known for its role in central nervous system, it is also expressed in peripheral tissues.
Bangning Yu, Diana M. Battaglia, Timothy P. Foster, Charles D. Nichols   +3 more
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St. John's wort extract STW3-VI affects the binding behaviour, signal transduction and lateral mobility of 5-HT2A receptors observed by single molecule detection and the use of a novel fluorescence-labeled ligand

Phytomedicine Plus, 2022
Background: 5-HT2A receptors play an important role in the development and therapy of depression. St. John's wort (SJW) extracts are used in the treatment of depression.
Stefan Aatz, Sebastian Franken, Christiane Kolb, Hanns Häberlein   +3 more
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Human Cortical Serotonin 2A Receptor Occupancy by Psilocybin Measured Using [11C]MDL 100,907 Dynamic PET and a Resting-State fMRI-Based Brain Parcellation

Frontiers in Neuroergonomics, 2022
Psilocybin (a serotonin 2A, or 5-HT2A, receptor agonist) has shown preliminary efficacy as a treatment for mood and substance use disorders. The current report utilized positron emission tomography (PET) with the selective 5-HT2A receptor inverse agonist
Frederick S. Barrett, Frederick S. Barrett, Yun Zhou, Theresa M. Carbonaro, Joshua M. Roberts, Gwenn S. Smith, Gwenn S. Smith, Roland R. Griffiths, Roland R. Griffiths, Dean F. Wong   +9 more
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Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines

Frontiers in Pharmacology, 2022
3,4,5-Trimethoxyphenethylamine (mescaline) is a psychedelic alkaloid found in peyote cactus. Related 4-alkoxy-3,5-dimethoxy-substituted phenethylamines (scalines) and amphetamines (3C-scalines) are reported to induce similarly potent psychedelic effects ...
Karolina E. Kolaczynska, Dino Luethi, Dino Luethi, Daniel Trachsel, Marius C. Hoener, Matthias E. Liechti   +5 more
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The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster

Frontiers in Aging, 2022
The conserved neurotransmitter serotonin has been shown to be an important modulator of lifespan in specific nutritional contexts; however, it remained unclear how serotonin signaling influences lifespan under normal conditions.
Allyson S. Munneke, Tuhin S. Chakraborty, Saige S. Porter, Christi M. Gendron, Scott D. Pletcher, Scott D. Pletcher, Scott D. Pletcher   +6 more
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Serotonergic signals enhanced hamster sperm hyperactivation

The Journal of Reproduction and Development, 2021
In the present study, we investigated the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters. First, we examined the types of 5-HT receptors that regulate hyperactivation.
Chiyori SAKAMOTO, Masakatsu FUJINOKI, Masafumi KITAZAWA, Satoshi OBAYASHI   +3 more
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