Results 41 to 50 of about 167,106 (231)

BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures

, 2009
Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT2A) have been related to depression pathology. Specific 5-HT2A receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT2A receptor level ...
Santini, M.A., Mikkelsen, J. D., Hansen, H. H., Kokaia, Merab, Kokaia, M., Marcussen, A. B., Arneberg, L., Knudsen, G. M., Aznar, S., Marcussen, A.B, Santini, M. A., Thomsen, M.S., Hansen, H.H., Knudsen, G.M., Trajkovska, V., Kokaia, Merab,, Mikkelsen, J.D., Thomsen, M. S., Aznar, S   +18 more
core   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Existence of Brain 5‐HT1A−5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor−Receptor Interactions Regulating 5‐HT1A Receptor Recognition [PDF]

, 2017
Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are ...
David Savelli, Shumilov, Kirill, Bartosz Pomierny, Zaida Díaz-Cabiale, CUPPINI, RICCARDO, Pomierny, Bartosz, AMBROGINI, PATRIZIA, Maria Lindskog, Alexander O. Tarakanov, Tarakanov, Alexander O., Dasiel O. Borroto-Escuela, Li, Xiang, Jimenez Beristain, Antonio, Andrade Talavera, Yuniesky, Lindskog, Maria, SAVELLI, DAVID, BORROTO ESCUELA, DASIEL OSCAR, Manuel Narváez, Xiang Li, Antonio Jimenez-Beristain, Fuxe, Kjell, Kjell Fuxe, Yuniesky Andrade-Talavera, Díaz Cabiale, Zaida, Narvaez, Manuel, Riccardo Cuppini, Patrizia Ambrogini, Kirill Shumilov   +27 more
core   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Effects of Constant Flickering Light on Refractive Status, 5-HT and 5-HT2A Receptor in Guinea Pigs. [PDF]

PLoS ONE, 2016
To investigate the effects of constant flickering light on refractive development, the role of serotonin (i.e.5-hydroxytryptamine, 5-HT)and 5-HT2A receptor in myopia induced by flickering light in guinea pigs.Forty-five guinea pigs were randomly divided ...
Bing Li, Xiumei Luo, Tao Li, Changyue Zheng, Shunmei Ji, Yuanyuan Ma, Shuangshuang Zhang, Xiaodong Zhou   +7 more
doaj   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Safety pharmacology of acute mescaline administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber, Mélusine Humbert‐Droz, Laura Ley, Yasmin Schmid, Matthias E. Liechti   +4 more
wiley   +1 more source

Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice

Journal of Diabetes Research, 2018
A recent report suggested that brain-derived serotonin (5-HT) is critical for maintaining weight loss induced by glucagon-like peptide-1 (GLP-1) receptor activation in rats and that 5-HT2A receptors mediate the feeding suppression and weight loss induced
Katsunori Nonogaki, Takao Kaji
doaj   +1 more source

The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats Efeito sobre o comportamento materno agressivo de ratos da microinjeção do agonista seletivo de receptores 5-HT2a/2c no núcleo central da amígdala e na área pré-óptica medial

Brazilian Journal of Psychiatry, 2006
OBJECTIVE: Much evidence supports the hypothesis that 5-hydroxytryptamine (5-HT) activation is related to the inhibition of aggression. We examined potentially pro- and anti-aggressive effects of the 5-HT2A/2C receptor agonist on specific brain sites ...
Rosa Maria Martins de Almeida, Marcia Giovenardi, Simone Perroni da Silva, Verônica Paz de Oliveira, Dirson João Stein   +4 more
doaj   +1 more source

Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling

, 2009
The 5-hydroxytryptamine 2A (5-HT2A) receptor is a member of the G protein-coupled receptor superfamily (GPCR) and plays a key role in transducing a variety of cellular signals elicited by 5-hydroxytryptamine in both peripheral and central tissues ...
Strachan, R.T., Willard, B., Kinter, Michael, Strachan, Ryan T., Sheffler, D.J., Sheffler, Douglas J., Willard, Belinda, Roth, Bryan L., Kinter, M., Kiselar, Janna G., Roth, B.L., Kiselar, J.G.   +11 more
core   +1 more source