Results 31 to 40 of about 167,106 (231)
European Psychiatry, 2021 Introduction Autism Spectrum Disorder and Social Anxiety Disorder are mental illnesses characterized by a dysfunction in social behavior (SB); a phenomenon largely mediated by the medial prefrontal cortex (mPFC). Clinical studies have demonstrated that
A. Markopoulos +3 more
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Neuronal localization of the 5-HT2 receptor family in the amygdaloid complex
Frontiers in Pharmacology, 2014 The amygdaloid complex (or amygdala), a heterogeneous structure located in the medial portion of the temporal lobe, is composed of deep, superficial, and remaining nuclei.
Cristiano eBombardi
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Scientific Reports, 2020 5-HT2A, a G-protein coupled receptor, is widely expressed in the human body, including in the gastrointestinal tract, platelets and the nervous system. It mediates various functions, for e.g.
Joe Anand Kumar John Jayakumar +2 more
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Role of 5-HT2A receptor antagonists in the treatment of insomnia
Nature and Science of Sleep, 2010 Insomnia encompasses a difficulty in falling asleep (sleep-onset insomnia) and/or a difficulty in staying asleep (SMI). Several selective serotonin-2A (5-HT2A) receptor antagonists have been in development as potential treatments for SMI. However, none have shown a sufficiently robust benefit-to-risk ratio, and none have reached market approval.
Kimberly E, Vanover, Robert E, Davis
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The T102C Polymorphism of the 5-HT2A-Receptor Gene in Fibromyalgia
Neurobiology of Disease, 1999 Based on a possible involvement of serotonergic dysfunction in the pathophysiology of fibromyalgia (FM) and on preliminary reports of a possible genetically driven vulnerability for this disorder we investigated the silent T102C polymorphism of the 5-HT2A-receptor gene in 168 FM patients and 115 healthy controls.
Brigitta Bondy +11 more
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Molecules, 2015 5-Hydroxytryptamine type 2A (5-HT2A) receptor is an important target for developing innovative antipsychotic agents in neuropsychiatric disorder therapies.
Lijian Ding +8 more
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Regulation of 5-HT2A receptor mRNA in P11 cells
Behavioural Brain Research, 1995 P11 cells were used as an in vitro model system to explore effects of exposure to 5-HT on levels of mRNA encoding 5-HT2A receptors. Exposure of cells to the agonist 5-HT resulted in a doubling of receptor mRNA levels. mRNA levels returned to control levels within 8-16 h.
R C, Ferry, P B, Molinoff
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Enhanced effect of the hallucinogen DOI in L-DOPA receptor Gpr143-deficient mice
Journal of Pharmacological SciencesHallucinogens, such as lysergic acid diethylamide, act primarily through the 5-hydroxytryptamine 2A (5-HT2A) receptor, but their regulatory mechanisms remain unclear.
Daiki Masukawa +5 more
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Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT2A receptor
, 2020 The 5-HT2A receptor is a target for hallucinogenic and non-hallucinogenic ligands that evoke unique behavioral, electrophysiological and molecular consequences.
Vaidya, Vidita A., Banerjee, Antara A.
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Animal Models and Experimental Medicine, EarlyView.The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan +6 more
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