Results 61 to 70 of about 167,106 (231)

Caracterização da contração induzida por serotonina em corpo cavernoso de rato: Luigi Marins Berretta ; orientadora, Áurea Elizabeth Linder [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.A disfunção erétil pode ser definida como a dificuldade parcial ou total de se obter e/ou ...
Berretta, Luigi Marins
core  

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 94-108, July 2026.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Specificity of 5‐HT2A Receptor Ligands in Mice

The FASEB Journal, 2008
In‐Vitro studies of RNA editing of the serotonin type 2C receptor (5‐HT2CR) have shown a pronounced loss of function in the fully edited isoform (VGV). Our goal is to evaluate functional coupling of the edited 5‐HT2CR in‐vivo using transgenic mice that solely express the VGV isoform.
Uade Olaghere da Silva, Elaine Sanders‐Bush   +1 more
openaire   +1 more source

LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT2A receptor [PDF]

, 2009
Compounds that activate the 5-HT2A receptor, such as lysergic acid diethylamide (LSD), act as hallucinogens in humans. One notable exception is the LSD congener lisuride, which does not have hallucinogenic effects in humans even though it is a potent 5 ...
Geyer, Mark A., Mark A. Geyer, Adam L. Halberstadt, Halberstadt, Adam L.   +3 more
core   +1 more source

Image2_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf

, 2022
The conserved neurotransmitter serotonin has been shown to be an important modulator of lifespan in specific nutritional contexts; however, it remained unclear how serotonin signaling influences lifespan under normal conditions.
Saige S. Porter (14200154), Allyson S. Munneke (14200148), Scott D. Pletcher (8798339), Christi M. Gendron (14200157), Tuhin S. Chakraborty (14200151)   +4 more
core   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Decreased density of serotonin 5-HT2A receptors in rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2006
Animal studies have indicated that 5-HT2A receptors could play a role in arthritic diseases.To analyse the binding properties of 5-HT2A receptors in patients with rheumatoid arthritis.Using a radioactive binding assay, 43 patients with rheumatoid arthritis were compared with 49 sex and age matched controls for density and affinity (measured as Bmax and
A, Kling, S, Rantapää-Dahlqvist, H, Stenlund, T, Mjörndal   +3 more
openaire   +2 more sources

Platelet Serotonin (5-HT)2A Receptor Binding Sites in Affective Disorders: A Quantitative Receptor Autoradiographic Study with [ 125I ] Lysergic Acid Diethylamide [PDF]

, 1998
We used the quantitative receptor autoradiographic method with a radioligand of [ 125I ]lysergic acid diethylamide ([125I]LSD) to quantitate platelet serotonin (5-HT)2A receptors in affective disorders.
Asou, Tadafumi, Himeno, Akihiko, Tsujimura, Toru, Nakane, Yoshibumi, Hayashida, Masaki   +4 more
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Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression.

, 1995
We investigated the effect of electroconvulsive shock (ECS), administered five times over 10 days, on 5-HT1A and 5-HT2A receptor mRNA and binding site densities in the rat brain using in situ hybridization histochemistry and quantitative autoradiography.
Burnet, PW, Harrison, PJ, Lacey, K, Mead, A, Eastwood, SL, Sharp, T   +5 more
core   +1 more source

The Australia story: Current status and future challenges for the clinical applications of psychedelics

British Journal of Pharmacology, Volume 183, Issue 14, Page 4048-4057, July 2026.
Abstract The past decade has seen a huge increase in clinical research with psychedelic drugs and 3,4‐methylenedioxymethamphetamine (MDMA), which have revealed great potential for treating mental health conditions. Given this progress in research, as well as the current unmet clinical need of millions of patients, in 2023, the Australian Therapeutic ...
David J Nutt, Peter Hunt, Anne Katrin Schlag, Paul Fitzgerald   +3 more
wiley   +1 more source