Results 1 to 10 of about 22,802 (228)
The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster
Frontiers in Aging, 2022 The conserved neurotransmitter serotonin has been shown to be an important modulator of lifespan in specific nutritional contexts; however, it remained unclear how serotonin signaling influences lifespan under normal conditions.
Allyson S. Munneke +6 more
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Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT2A [PDF]
Nature CommunicationsG protein-coupled receptor (GPCR) dimers and higher-order oligomers are the subject of intense debates. The complexes formed between two or more different GPCRs enable the cell to integrate several signals.
Siyu Gai +13 more
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Serotonin 2a Receptor and serotonin 1a receptor interact within the medial prefrontal cortex during recognition memory in mice [PDF]
Frontiers in Pharmacology, 2015 Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it.
Juan Facundo Morici +6 more
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Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning. [PDF]
PLoS BiologySynapse connectivity is optimized in response to environmental input in critical periods, characterized by experience-dependent, temporally-restricted, and transiently-reversible synapse pruning by glial phagocytes.
Vanessa Kay Miller, Kendal Broadie
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Frontiers in Neuroergonomics, 2022 Psilocybin (a serotonin 2A, or 5-HT2A, receptor agonist) has shown preliminary efficacy as a treatment for mood and substance use disorders. The current report utilized positron emission tomography (PET) with the selective 5-HT2A receptor inverse agonist
Frederick S. Barrett +9 more
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The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. [PDF]
PLoS ONE, 2014 There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states.
Olivia A Lin +4 more
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PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization
Frontiers in Endocrinology, 2021 Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Heterozygous Pacap mutant mice show
Atsuko Hayata-Takano +12 more
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Scientific Reports, 2021 Serotonin 5-HT2 receptors are expressed in many tissues and play important roles in biological processes. Although the 5-HT2A receptor is primarily known for its role in central nervous system, it is also expressed in peripheral tissues.
Bangning Yu +3 more
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Renal Replacement Therapy, 2020 Chronic kidney diseases (CKD) are an economic burden and occur worldwide in all age groups, and the advancement of kidney disease at some point leads to deregulate or influence the function of other body organs and to find a specific target to halt the ...
Gagandeep Kaur, Pawan Krishan
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Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo. [PDF]
PLoS ONE, 2013 Tumor necrosis factor alpha (TNF-α) plays a key role in inflammation, and its production and signaling contribute to many inflammatory related diseases.
Felix Nau +3 more
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